Names & Taxonomy
- Uniprot ID:
- O14727
- Entry Name:
- APAF_HUMAN
- Status:
- reviewed
- Protein Names:
- Apoptotic protease-activating factor 1 (APAF-1)
- Gene Names:
- APAF1 KIAA0413
- Gene Names Primary:
- APAF1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1248
- Sequence:
- MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
- Cross Reference Drug Bank:
- DB00171
- Gene Ontology Go:
- apoptosome
cytosol
extracellular exosome
nucleus
ADP binding
ATP binding
cysteine-type endopeptidase activator activity involved in apoptotic process
nucleotide binding
activation of cysteine-type endopeptidase activity involved in apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
aging
apoptotic process
cardiac muscle cell apoptotic process
cell differentiation
cellular response to transforming growth factor beta stimulus
forebrain development
glial cell apoptotic process
intrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
nervous system development
neural tube closure
neuron apoptotic process
positive regulation of apoptotic process
positive regulation of apoptotic signaling pathway
programmed cell death
protein homooligomerization
regulation of apoptotic DNA fragmentation
regulation of apoptotic process
response to G1 DNA damage checkpoint signaling
response to hypoxia
response to nutrient - Gene Ontology Biological Process:
- activation of cysteine-type endopeptidase activity involved in apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
aging
apoptotic process
cardiac muscle cell apoptotic process
cell differentiation
cellular response to transforming growth factor beta stimulus
forebrain development
glial cell apoptotic process
intrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
nervous system development
neural tube closure
neuron apoptotic process
positive regulation of apoptotic process
positive regulation of apoptotic signaling pathway
programmed cell death
protein homooligomerization
regulation of apoptotic DNA fragmentation
regulation of apoptotic process
response to G1 DNA damage checkpoint signaling
response to hypoxia
response to nutrient - Gene Ontology Molecular Function:
- ADP binding
ATP binding
cysteine-type endopeptidase activator activity involved in apoptotic process
nucleotide binding - Gene Ontology Cellular Component:
- apoptosome
cytosol
extracellular exosome
nucleus - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Apoptosis
Calcium
Complete proteome
Cytoplasm
Direct protein sequencing
Nucleotide-binding
Reference proteome
Repeat
WD repeat - Interacts With:
- P55211; P99999; P62136; P62258