Names & Taxonomy
- Uniprot ID:
- O14649
- Entry Name:
- KCNK3_HUMAN
- Status:
- reviewed
- Protein Names:
- Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Two pore potassium channel KT3.1) (Two pore K(+) channel KT3.1)
- Gene Names:
- KCNK3 TASK TASK1
- Gene Names Primary:
- KCNK3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 394
- Sequence:
- MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELRQQELRARYNLSQGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTLVRYLLHRAKKGLGMRRADVSMANMVLIGFFSCISTLCIGAAAFSHYEHWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTRNGQAGGGGGGGSAHTTDTASSTAAAGGGGFRNVYAEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEQSHSSPGGGGRYSDTPSRRCLCSGAPRSAISSVSTGLHSLSTFRGLMKRRSSV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
- Intramembrane:
- INTRAMEM 78 101 Pore-forming; Name=Pore-forming 1.
Function
- Function:
- pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.
- Cross Reference Drug Bank:
- DB00561 DB01159
- Gene Ontology Go:
- cytosol
integral component of plasma membrane
plasma membrane
ion channel activity
open rectifier potassium channel activity
potassium channel activity
potassium ion leak channel activity
S100 protein binding
brain development
cardiac conduction
cellular response to hypoxia
cellular response to zinc ion
cochlea development
ion transmembrane transport
mitophagy in response to mitochondrial depolarization
negative regulation of cytosolic calcium ion concentration
potassium ion transport
response to drug
stabilization of membrane potential
synaptic transmission - Gene Ontology Biological Process:
- brain development
cardiac conduction
cellular response to hypoxia
cellular response to zinc ion
cochlea development
ion transmembrane transport
mitophagy in response to mitochondrial depolarization
negative regulation of cytosolic calcium ion concentration
potassium ion transport
response to drug
stabilization of membrane potential
synaptic transmission - Gene Ontology Molecular Function:
- ion channel activity
open rectifier potassium channel activity
potassium channel activity
potassium ion leak channel activity
S100 protein binding - Gene Ontology Cellular Component:
- cytosol
integral component of plasma membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Disease mutation
Glycoprotein
Ion channel
Ion transport
Membrane
Potassium
Potassium channel
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport