Names & Taxonomy
- Uniprot ID:
- O14556
- Entry Name:
- G3PT_HUMAN
- Status:
- reviewed
- Protein Names:
- Glyceraldehyde-3-phosphate dehydrogenase, testis-specific (EC 1.2.1.12) (Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2) (GAPDH-2) (Spermatogenic glyceraldehyde-3-phosphate dehydrogenase)
- Gene Names:
- GAPDHS GAPD2 GAPDH2 GAPDS HSD-35 HSD35
- Gene Names Orf:
- HSD-35 HSD35
- Gene Names Primary:
- GAPDHS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 408
- Sequence:
- MSKRDIVLTNVTVVQLLRQPCPVTRAPPPPEPKAEVEPQPQPEPTPVREEIKPPPPPLPPHPATPPPKMVSVARELTVGINGFGRIGRLVLRACMEKGVKVVAVNDPFIDPEYMVYMFKYDSTHGRYKGSVEFRNGQLVVDNHEISVYQCKEPKQIPWRAVGSPYVVESTGVYLSIQAASDHISAGAQRVVISAPSPDAPMFVMGVNENDYNPGSMNIVSNASCTTNCLAPLAKVIHERFGIVEGLMTTVHSYTATQKTVDGPSRKAWRDGRGAHQNIIPASTGAAKAVTKVIPELKGKLTGMAFRVPTPDVSVVDLTCRLAQPAPYSAIKEAVKAAAKGPMAGILAYTEDEVVSTDFLGDTHSSIFDAKAGIALNDNFVKLISWYDNEYGYSHRVVDLLRYMFSRDK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity).
- Pathway:
- Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.
- Catalytic Activity:
- D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH.
- Active Site:
- ACT_SITE 224 224 Nucleophile.
- Gene Ontology Go:
- cytosol
motile cilium
nucleus
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NAD binding
NADP binding
canonical glycolysis
carbohydrate metabolic process
gluconeogenesis
glucose metabolic process
positive regulation of glycolytic process
small molecule metabolic process
sperm motility
spermatid development - Gene Ontology Biological Process:
- canonical glycolysis
carbohydrate metabolic process
gluconeogenesis
glucose metabolic process
positive regulation of glycolytic process
small molecule metabolic process
spermatid development
sperm motility - Gene Ontology Molecular Function:
- glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NAD binding
NADP binding - Gene Ontology Cellular Component:
- cytosol
motile cilium
nucleus - Keywords:
- 3D-structure
Complete proteome
Cytoplasm
Glycolysis
NAD
Oxidoreductase
Polymorphism
Reference proteome