Names & Taxonomy
- Uniprot ID:
- O14521
- Entry Name:
- DHSD_HUMAN
- Status:
- reviewed
- Protein Names:
- Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial (CybS) (CII-4) (QPs3) (Succinate dehydrogenase complex subunit D) (Succinate-ubiquinone oxidoreductase cytochrome b small subunit) (Succinate-ubiquinone reductase membrane anchor subunit)
- Gene Names:
- SDHD SDH4
- Gene Names Primary:
- SDHD
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 159
- Sequence:
- MAVLWRLSAVCGALGGRALLLRTPVVRPAHISAFLQDRPIPEWCGVQHIHLSPSHHSGSKAASLHWTSERVVSVLLLGLLPAAYLNPCSAMDYSLAAALTLHGHWGLGQVVTDYVHGDALQKAAKAGLLALSALTFAGLCYFNYHDVGICKAVAMLWKL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane; Multi-pass membrane protein.
Function
- Function:
- Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
- Pathway:
- Carbohydrate metabolism; tricarboxylic acid cycle.
- Cross Reference Drug Bank:
- DB00756 DB00139
- Gene Ontology Go:
- integral component of membrane
mitochondrial envelope
mitochondrial inner membrane
mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)
mitochondrion
electron carrier activity
heme binding
metal ion binding
succinate dehydrogenase activity
ubiquinone binding
cellular metabolic process
respiratory electron transport chain
small molecule metabolic process
tricarboxylic acid cycle - Gene Ontology Biological Process:
- cellular metabolic process
respiratory electron transport chain
small molecule metabolic process
tricarboxylic acid cycle - Gene Ontology Molecular Function:
- electron carrier activity
heme binding
metal ion binding
succinate dehydrogenase activity
ubiquinone binding - Gene Ontology Cellular Component:
- integral component of membrane
mitochondrial envelope
mitochondrial inner membrane
mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)
mitochondrion - Keywords:
- Alternative splicing
Complete proteome
Disease mutation
Electron transport
Heme
Iron
Membrane
Metal-binding
Mitochondrion
Mitochondrion inner membrane
Polymorphism
Reference proteome
Transit peptide
Transmembrane
Transmembrane helix
Transport
Tricarboxylic acid cycle