Names & Taxonomy
- Uniprot ID:
- O00755
- Entry Name:
- WNT7A_HUMAN
- Status:
- reviewed
- Protein Names:
- Protein Wnt-7a
- Gene Names:
- WNT7A
- Gene Names Primary:
- WNT7A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 349
- Sequence:
- MNRKARRCLGHLFLSLGMVYLRIGGFSSVVALGASIICNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITAACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix.
Function
- Function:
- Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts (By similarity).
- Gene Ontology Go:
- cell surface
endocytic vesicle membrane
endoplasmic reticulum lumen
extracellular exosome
extracellular region
extracellular space
Golgi lumen
plasma membrane
presynapse
proteinaceous extracellular matrix
cytokine activity
frizzled binding
receptor agonist activity
receptor binding
angiogenesis
asymmetric protein localization
axonogenesis
canonical Wnt signaling pathway
cartilage condensation
cell fate commitment
cell proliferation in forebrain
cellular response to transforming growth factor beta stimulus
central nervous system vasculogenesis
cerebellar granule cell differentiation
chondrocyte differentiation
dendritic spine morphogenesis
dorsal/ventral pattern formation
embryonic axis specification
embryonic digit morphogenesis
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
establishment of cell polarity
excitatory synapse assembly
lens fiber cell development
negative regulation of apoptotic process
negative regulation of neurogenesis
neuron differentiation
neurotransmitter secretion
non-canonical Wnt signaling pathway
oviduct development
palate development
positive regulation of canonical Wnt signaling pathway
positive regulation of endothelial cell migration
positive regulation of epithelial cell proliferation involved in wound healing
positive regulation of excitatory postsynaptic potential
positive regulation of excitatory synapse assembly
positive regulation of JNK cascade
positive regulation of protein localization to synapse
positive regulation of synapse assembly
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
regulation of axon diameter
response to estradiol
sex differentiation
skeletal muscle satellite cell activation
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
somatic stem cell division
somatic stem cell population maintenance
stem cell development
synapse assembly
synaptic vesicle recycling
uterus morphogenesis
Wnt signaling pathway involved in wound healing, spreading of epidermal cells - Gene Ontology Biological Process:
- angiogenesis
asymmetric protein localization
axonogenesis
canonical Wnt signaling pathway
cartilage condensation
cell fate commitment
cell proliferation in forebrain
cellular response to transforming growth factor beta stimulus
central nervous system vasculogenesis
cerebellar granule cell differentiation
chondrocyte differentiation
dendritic spine morphogenesis
dorsal/ventral pattern formation
embryonic axis specification
embryonic digit morphogenesis
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
establishment of cell polarity
excitatory synapse assembly
lens fiber cell development
negative regulation of apoptotic process
negative regulation of neurogenesis
neuron differentiation
neurotransmitter secretion
non-canonical Wnt signaling pathway
oviduct development
palate development
positive regulation of canonical Wnt signaling pathway
positive regulation of endothelial cell migration
positive regulation of epithelial cell proliferation involved in wound healing
positive regulation of excitatory postsynaptic potential
positive regulation of excitatory synapse assembly
positive regulation of JNK cascade
positive regulation of protein localization to synapse
positive regulation of synapse assembly
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of axon diameter
response to estradiol
sex differentiation
skeletal muscle satellite cell activation
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
somatic stem cell division
somatic stem cell population maintenance
stem cell development
synapse assembly
synaptic vesicle recycling
uterus morphogenesis
Wnt signaling pathway involved in wound healing, spreading of epidermal cells - Gene Ontology Molecular Function:
- cytokine activity
frizzled binding
receptor agonist activity
receptor binding - Gene Ontology Cellular Component:
- cell surface
endocytic vesicle membrane
endoplasmic reticulum lumen
extracellular exosome
extracellular region
extracellular space
Golgi lumen
plasma membrane
presynapse
proteinaceous extracellular matrix - Keywords:
- 3D-structure
Complete proteome
Developmental protein
Disease mutation
Disulfide bond
Extracellular matrix
Glycoprotein
Lipoprotein
Reference proteome
Secreted
Signal
Wnt signaling pathway - Interacts With:
- Q9Y5W5