Names & Taxonomy

Uniprot ID:
O00748
Entry Name:
EST2_HUMAN
Status:
reviewed
Protein Names:
Cocaine esterase (EC 3.1.1.84) (Carboxylesterase 2) (CE-2) (hCE-2) (EC 3.1.1.1) (Methylumbelliferyl-acetate deacetylase 2) (EC 3.1.1.56)
Gene Names:
CES2 ICE
Gene Names Primary:
CES2
Organism:
Homo sapiens (Human)

Structure

Length:
559
Sequence:
MRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQYRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEILAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMFVIPALQVAHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADHGDELPFVFRSFFGGNYIKFTEEEEQLSRKMMKYWANFARNGNPNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQELEEPEERHTEL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum lumen

Function

Function:
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine.
Catalytic Activity:
Cocaine + H(2)O = ecgonine methyl ester + benzoate.
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.39 mM for cocaine
Active Site:
ACT_SITE 228 228 Acyl-ester intermediate.
Cross Reference Drug Bank:
DB06695 DB00762 DB00688 DB06209
Gene Ontology Go:
endoplasmic reticulum
endoplasmic reticulum lumen
extracellular space
carboxylic ester hydrolase activity
methylumbelliferyl-acetate deacetylase activity
catabolic process
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
catabolic process
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
carboxylic ester hydrolase activity
methylumbelliferyl-acetate deacetylase activity
Gene Ontology Cellular Component:
endoplasmic reticulum
endoplasmic reticulum lumen
extracellular space
Keywords:
Alternative splicing
Complete proteome
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Hydrolase
Polymorphism
Pyrrolidone carboxylic acid
Reference proteome
Serine esterase
Signal

Publication

PubMed ID:
9144407 9169443 14702039 17974005 15616553 15489334 19159218 21269460 24275569 12721789 15618752