Names & Taxonomy
- Uniprot ID:
- O00748
- Entry Name:
- EST2_HUMAN
- Status:
- reviewed
- Protein Names:
- Cocaine esterase (EC 3.1.1.84) (Carboxylesterase 2) (CE-2) (hCE-2) (EC 3.1.1.1) (Methylumbelliferyl-acetate deacetylase 2) (EC 3.1.1.56)
- Gene Names:
- CES2 ICE
- Gene Names Primary:
- CES2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 559
- Sequence:
- MRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQYRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEILAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMFVIPALQVAHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADHGDELPFVFRSFFGGNYIKFTEEEEQLSRKMMKYWANFARNGNPNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQELEEPEERHTEL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum lumen
Function
- Function:
- Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine.
- Catalytic Activity:
- Cocaine + H(2)O = ecgonine methyl ester + benzoate.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.39 mM for cocaine
- Active Site:
- ACT_SITE 228 228 Acyl-ester intermediate.
- Cross Reference Drug Bank:
- DB06695 DB00762 DB00688 DB06209
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum lumen
extracellular space
carboxylic ester hydrolase activity
methylumbelliferyl-acetate deacetylase activity
catabolic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- catabolic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- carboxylic ester hydrolase activity
methylumbelliferyl-acetate deacetylase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum lumen
extracellular space - Keywords:
- Alternative splicing
Complete proteome
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Hydrolase
Polymorphism
Pyrrolidone carboxylic acid
Reference proteome
Serine esterase
Signal