Names & Taxonomy
- Uniprot ID:
- O00591
- Entry Name:
- GBRP_HUMAN
- Status:
- reviewed
- Protein Names:
- Gamma-aminobutyric acid receptor subunit pi (GABA(A) receptor subunit pi)
- Gene Names:
- GABRP
- Gene Names Primary:
- GABRP
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 440
- Sequence:
- MNYSLHLAFVCLSLFTERMCIQGSQFNVEVGRSDKLSLPGFENLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEGNKSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTRSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAKDRGTTKEVEEVSITNIINSSISSFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVFREKMGRIVDYFTIQNPSNVDHYSKLLFPLIFMLANVFYWAYYMYF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Function
- Function:
- GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.
- Cross Reference Drug Bank:
- DB00659 DB00546 DB00404 DB00543 DB01558 DB00237 DB00241 DB00475 DB01594 DB00349 DB01068 DB00628 DB01559 DB01189 DB00829 DB00228 DB01049 DB01215 DB00402 DB00898 DB00189 DB00292 DB01567 DB01205 DB00690 DB01437 DB00801 DB01159 DB00753 DB00186 DB00371 DB01028 DB01107 DB00683 DB01595 DB00334 DB00842 DB00312 DB01588 DB00794 DB00818 DB01589 DB01236 DB00306 DB00231 DB00273 DB00897
- Gene Ontology Go:
- cell junction
chloride channel complex
postsynaptic membrane
extracellular-glutamate-gated chloride channel activity
GABA-A receptor activity
chloride transmembrane transport
signal transduction - Gene Ontology Biological Process:
- chloride transmembrane transport
signal transduction - Gene Ontology Molecular Function:
- extracellular-glutamate-gated chloride channel activity
GABA-A receptor activity - Gene Ontology Cellular Component:
- cell junction
chloride channel complex
postsynaptic membrane - Keywords:
- Cell junction
Cell membrane
Chloride
Chloride channel
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Membrane
Polymorphism
Postsynaptic cell membrane
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport