Names & Taxonomy
- Uniprot ID:
- O00555
- Entry Name:
- CAC1A_HUMAN
- Status:
- reviewed
- Protein Names:
- Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Brain calcium channel I) (BI) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Voltage-gated calcium channel subunit alpha Cav2.1)
- Gene Names:
- CACNA1A CACH4 CACN3 CACNL1A4
- Gene Names Primary:
- CACNA1A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 2505
- Sequence:
- MARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHLDRPLVVDPQENRNNNTNKSRAAEPTVDQRLGQQRAEDFLRKQARYHDRARDPSGSAGLDARRPWAGSQEAELSREGPYGRESDHHAREGSLEQPGFWEGEAERGKAGDPHRRHVHRQGGSRESRSGSPRTGADGEHRRHRAHRRPGEEGPEDKAERRARHREGSRPARGGEGEGEGPDGGERRRRHRHGAPATYEGDARREDKERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDPPLAEDIDNMKNNKLATAESAAPHGSLGHAGLPQSPAKMGNSTDPGPMLAIPAMATNPQNAASRRTPNNPGNPSNPGPPKTPENSLIVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRMPYLDMYQMLRHMSPPLGLGKKCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREEQDRTPLMFQRMEPPSPTQEGGPGQNALPSTQLDPGGALMAHESGLKESPSWVTQRAQEMFQKTGTWSPEQGPPTDMPNSQPNSQSVEMREMGRDGYSDSEHYLPMEGQGRAASMPRLPAENQRRRGRPRGNNLSTISDTSPMKRSASVLGPKARRLDDYSLERVPPEENQRHHQRRRDRSHRASERSLGRYTDVDTGLGTDLSMTTQSGDLPSKERDQERGRPKDRKHRQHHHHHHHHHHPPPPDKDRYAQERPDHGRARARDQRWSRSPSEGREHMAHRQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPSTPRPHVSYSPVIRKAGGSGPPQQQQQQQQQQQAVARPGRAATSGPRRYPGPTAEPLAGDRPPTGGHSSGRSPRMERRVPGPARSESPRACRHGGARWPASGPHVSEGPPGPRHHGYYRGSDYDEADGPGSGGGEEAMAGAYDAPPPVRHASSGATGRSPRTPRASGPACASPSRHGRRLPNGYYPAHGLARPRGPGSRKGLHEPYSESDDDWC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).
- Cross Reference Drug Bank:
- DB01244 DB00836 DB00230 DB00421 DB00661
- Gene Ontology Go:
- cell projection
cytoplasm
dendrite
integral component of membrane
neuronal cell body
nucleus
plasma membrane
presynapse
voltage-gated calcium channel complex
high voltage-gated calcium channel activity
metal ion binding
syntaxin binding
voltage-gated calcium channel activity
adult walking behavior
behavioral response to pain
calcium ion-regulated exocytosis of neurotransmitter
cell death
cell growth
cellular chloride ion homeostasis
cerebellar molecular layer development
cerebellar Purkinje cell differentiation
cerebellum maturation
dendrite morphogenesis
energy reserve metabolic process
gamma-aminobutyric acid secretion
gamma-aminobutyric acid signaling pathway
glucose metabolic process
hormone metabolic process
membrane depolarization
membrane depolarization during action potential
musculoskeletal movement, spinal reflex action
negative regulation of hormone biosynthetic process
negative regulation of neuron apoptotic process
neuromuscular process controlling balance
neuromuscular synaptic transmission
neurotransmitter metabolic process
positive regulation of cytosolic calcium ion concentration
receptor clustering
regulation of acetylcholine secretion, neurotransmission
regulation of axonogenesis
regulation of calcium ion-dependent exocytosis
regulation of insulin secretion
rhythmic synaptic transmission
small molecule metabolic process
spinal cord motor neuron differentiation
sulfur amino acid metabolic process
synapse assembly
synaptic transmission
synaptic transmission, glutamatergic
transmission of nerve impulse
vestibular nucleus development - Gene Ontology Biological Process:
- adult walking behavior
behavioral response to pain
calcium ion-regulated exocytosis of neurotransmitter
cell death
cell growth
cellular chloride ion homeostasis
cerebellar molecular layer development
cerebellar Purkinje cell differentiation
cerebellum maturation
dendrite morphogenesis
energy reserve metabolic process
gamma-aminobutyric acid secretion
gamma-aminobutyric acid signaling pathway
glucose metabolic process
hormone metabolic process
membrane depolarization
membrane depolarization during action potential
musculoskeletal movement, spinal reflex action
negative regulation of hormone biosynthetic process
negative regulation of neuron apoptotic process
neuromuscular process controlling balance
neuromuscular synaptic transmission
neurotransmitter metabolic process
positive regulation of cytosolic calcium ion concentration
receptor clustering
regulation of acetylcholine secretion, neurotransmission
regulation of axonogenesis
regulation of calcium ion-dependent exocytosis
regulation of insulin secretion
rhythmic synaptic transmission
small molecule metabolic process
spinal cord motor neuron differentiation
sulfur amino acid metabolic process
synapse assembly
synaptic transmission
synaptic transmission, glutamatergic
transmission of nerve impulse
vestibular nucleus development - Gene Ontology Molecular Function:
- high voltage-gated calcium channel activity
metal ion binding
syntaxin binding
voltage-gated calcium channel activity - Gene Ontology Cellular Component:
- cell projection
cytoplasm
dendrite
integral component of membrane
neuronal cell body
nucleus
plasma membrane
presynapse
voltage-gated calcium channel complex - Keywords:
- 3D-structure
Alternative splicing
Calcium
Calcium channel
Calcium transport
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Membrane
Metal-binding
Neurodegeneration
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Spinocerebellar ataxia
Transmembrane
Transmembrane helix
Transport
Triplet repeat expansion
Voltage-gated channel - Interacts With:
- Q8IZP0; O94910; Q86SJ2; Q7Z5H3; O95153; P67870; O75953; P28799; P15822; Q8N2S1; O00339; O75095; Q7Z7M0; Q9UHX1; Q8IXT5; Q9BVA1; P22695; P49750