Names & Taxonomy
- Uniprot ID:
- O00462
- Entry Name:
- MANBA_HUMAN
- Status:
- reviewed
- Protein Names:
- Beta-mannosidase (EC 3.2.1.25) (Lysosomal beta A mannosidase) (Mannanase) (Mannase)
- Gene Names:
- MANBA MANB1
- Gene Names Primary:
- MANBA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 879
- Sequence:
- MRLHLLLLLALCGAGTTAAELSYSLRGNWSICNGNGSLELPGAVPGCVHSALFQQGLIQDSYYRFNDLNYRWVSLDNWTYSKEFKIPFEISKWQKVNLILEGVDTVSKILFNEVTIGETDNMFNRYSFDITNVVRDVNSIELRFQSAVLYAAQQSKAHTRYQVPPDCPPLVQKGECHVNFVRKEQCSFSWDWGPSFPTQGIWKDVRIEAYNICHLNYFTFSPIYDKSAQEWNLEIESTFDVVSSKPVGGQVIVAIPKLQTQQTYSIELQPGKRIVELFVNISKNITVETWWPHGHGNQTGYNMTVLFELDGGLNIEKSAKVYFRTVELIEEPIKGSPGLSFYFKINGFPIFLKGSNWIPADSFQDRVTSELLRLLLQSVVDANMNTLRVWGGGIYEQDEFYELCDELGIMVWQDFMFACALYPTDQGFLDSVTAEVAYQIKRLKSHPSIIIWSGNNENEEALMMNWYHISFTDRPIYIKDYVTLYVKNIRELVLAGDKSRPFITSSPTNGAETVAEAWVSQNPNSNYFGDVHFYDYISDCWNWKVFPKARFASEYGYQSWPSFSTLEKVSSTEDWSFNSKFSLHRQHHEGGNKQMLYQAGLHFKLPQSTDPLRTFKDTIYLTQVMQAQCVKTETEFYRRSRSEIVDQQGHTMGALYWQLNDIWQAPSWASLEYGGKWKMLHYFAQNFFAPLLPVGFENENTFYIYGVSDLHSDYSMTLSVRVHTWSSLEPVCSRVTERFVMKGGEAVCLYEEPVSELLRRCGNCTRESCVVSFYLSADHELLSPTNYHFLSSPKEAVGLCKAQITAIISQQGDIFVFDLETSAVAPFVWLDVGSIPGRFSDNGFLMTEKTRTILFYPWEPTSKNELEQSFHVTSLTDIY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Lysosome.
Function
- Function:
- Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
- Pathway:
- Glycan metabolism; N-glycan degradation.
- Catalytic Activity:
- Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.
- Active Site:
- ACT_SITE 457 457 Proton donor.
- Gene Ontology Go:
- lysosome
beta-mannosidase activity
mannose binding
carbohydrate metabolic process
cellular protein modification process - Gene Ontology Biological Process:
- carbohydrate metabolic process
cellular protein modification process - Gene Ontology Molecular Function:
- beta-mannosidase activity
mannose binding - Gene Ontology Cellular Component:
- lysosome
- Keywords:
- Complete proteome
Glycoprotein
Glycosidase
Hydrolase
Lysosome
Polymorphism
Reference proteome
Signal