Names & Taxonomy
- Uniprot ID:
- O00358
- Entry Name:
- FOXE1_HUMAN
- Status:
- reviewed
- Protein Names:
- Forkhead box protein E1 (Forkhead box protein E2) (Forkhead-related protein FKHL15) (HFKH4) (HNF-3/fork head-like protein 5) (HFKL5) (Thyroid transcription factor 2) (TTF-2)
- Gene Names:
- FOXE1 FKHL15 FOXE2 TITF2 TTF2
- Gene Names Primary:
- FOXE1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 373
- Sequence:
- MTAESGPPPPQPEVLATVKEERGETAAGAGVPGEATGRGAGGRRRKRPLQRGKPPYSYIALIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNSIRHNLTLNDCFLKIPREAGRPGKGNYWALDPNAEDMFESGSFLRRRKRFKRSDLSTYPAYMHDAAAAAAAAAAAAAAAAIFPGAVPAARPPYPGAVYAGYAPPSLAAPPPVYYPAASPGPCRVFGLVPERPLSPELGPAPSGPGGSCAFASAGAPATTTGYQPAGCTGARPANPSAYAAAYAGPDGAYPQGAGSAIFAAAGRLAGPASPPAGGSSGGVETTVDFYGRTSPGQFGALGACYNPGGQLGGASAGAYHARHAAAYPGGIDRFVSAM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Probable transcription factor. Could be involved in thyroid gland organogenesis.
- Gene Ontology Go:
- nucleus
DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
transcription factor activity, sequence-specific DNA binding
anatomical structure morphogenesis
cell differentiation
cell migration
embryonic organ morphogenesis
hair follicle morphogenesis
hard palate development
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-templated
pharynx development
positive regulation of transcription, DNA-templated
soft palate development
thymus development
thyroid gland development
thyroid hormone generation
transcription, DNA-templated - Gene Ontology Biological Process:
- anatomical structure morphogenesis
cell differentiation
cell migration
embryonic organ morphogenesis
hair follicle morphogenesis
hard palate development
negative regulation of transcription, DNA-templated
negative regulation of transcription from RNA polymerase II promoter
pharynx development
positive regulation of transcription, DNA-templated
soft palate development
thymus development
thyroid gland development
thyroid hormone generation
transcription, DNA-templated - Gene Ontology Molecular Function:
- DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
transcription factor activity, sequence-specific DNA binding - Gene Ontology Cellular Component:
- nucleus
- Keywords:
- Complete proteome
DNA-binding
Disease mutation
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Transcription
Transcription regulation