Names & Taxonomy
- Uniprot ID:
- O00337
- Entry Name:
- S28A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium/nucleoside cotransporter 1 (Concentrative nucleoside transporter 1) (CNT 1) (hCNT1) (Na(+)/nucleoside cotransporter 1) (Sodium-coupled nucleoside transporter 1) (Solute carrier family 28 member 1)
- Gene Names:
- SLC28A1 CNT1
- Gene Names Primary:
- SLC28A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 649
- Sequence:
- MENDPSRRRESISLTPVAKGLENMGADFLESLEEGQLPRSDLSPAEIRSSWSEAAPKPFSRWRNLQPALRARSFCREHMQLFRWIGTGLLCTGLSAFLLVACLLDFQRALALFVLTCVVLTFLGHRLLKRLLGPKLRRFLKPQGHPRLLLWFKRGLALAAFLGLVLWLSLDTSQRPEQLVSFAGICVFVALLFACSKHHCAVSWRAVSWGLGLQFVLGLLVIRTEPGFIAFEWLGEQIRIFLSYTKAGSSFVFGEALVKDVFAFQVLPIIVFFSCVISVLYHVGLMQWVILKIAWLMQVTMGTTATETLSVAGNIFVSQTEAPLLIRPYLADMTLSEVHVVMTGGYATIAGSLLGAYISFGIDATSLIAASVMAAPCALALSKLVYPEVEESKFRREEGVKLTYGDAQNLIEAASTGAAISVKVVANIAANLIAFLAVLDFINAALSWLGDMVDIQGLSFQLICSYILRPVAFLMGVAWEDCPVVAELLGIKLFLNEFVAYQDLSKYKQRRLAGAEEWVGDRKQWISVRAEVLTTFALCGFANFSSIGIMLGGLTSMVPQRKSDFSQIVLRALFTGACVSLVNACMAGILYMPRGAEVDCMSLLNTTLSSSSFEIYQCCREAFQSVNPEFSPEALDNCCRFYNHTICAQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine.
- Cross Reference Drug Bank:
- DB00441 DB00649 DB00495
- Gene Ontology Go:
- apical plasma membrane
integral component of plasma membrane
membrane
plasma membrane
nucleoside transmembrane transporter activity
pyrimidine- and adenine-specific:sodium symporter activity
nucleobase-containing compound metabolic process
nucleoside transport
purine nucleobase transmembrane transport
transmembrane transport - Gene Ontology Biological Process:
- nucleobase-containing compound metabolic process
nucleoside transport
purine nucleobase transmembrane transport
transmembrane transport - Gene Ontology Molecular Function:
- nucleoside transmembrane transporter activity
pyrimidine- and adenine-specific:sodium symporter activity - Gene Ontology Cellular Component:
- apical plasma membrane
integral component of plasma membrane
membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Glycoprotein
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport