Names & Taxonomy
- Uniprot ID:
- O00222
- Entry Name:
- GRM8_HUMAN
- Status:
- reviewed
- Protein Names:
- Metabotropic glutamate receptor 8 (mGluR8)
- Gene Names:
- GRM8 GPRC1H MGLUR8
- Gene Names Primary:
- GRM8
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 908
- Sequence:
- MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
presynaptic membrane
G-protein coupled receptor activity
glutamate receptor activity
group III metabotropic glutamate receptor activity
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
negative regulation of cAMP biosynthetic process
sensory perception of smell
visual perception - Gene Ontology Biological Process:
- adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
negative regulation of cAMP biosynthetic process
sensory perception of smell
visual perception - Gene Ontology Molecular Function:
- glutamate receptor activity
G-protein coupled receptor activity
group III metabotropic glutamate receptor activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane
presynaptic membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Isopeptide bond
Membrane
Olfaction
Polymorphism
Receptor
Reference proteome
Sensory transduction
Signal
Transducer
Transmembrane
Transmembrane helix
Ubl conjugation