Names & Taxonomy
- Uniprot ID:
- H0YCY7
- Entry Name:
- H0YCY7_HUMAN
- Status:
- unreviewed
- Protein Names:
- Ribonucleoside-diphosphate reductase (EC 1.17.4.1) (Fragment)
- Gene Names:
- RRM1
- Gene Names Primary:
- RRM1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 130
- Sequence:
- XTYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRIMIYLPLASWGICYLPGALAFRHL
- Proteomes:
- UP000005640
Function
- Function:
- Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
- Pathway:
- Genetic information processing; DNA replication.
- Catalytic Activity:
- 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin.
- Gene Ontology Go:
- integral component of membrane
ATP binding
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
DNA replication - Gene Ontology Biological Process:
- DNA replication
- Gene Ontology Molecular Function:
- ATP binding
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor - Gene Ontology Cellular Component:
- integral component of membrane
- Keywords:
- Complete proteome
DNA replication
Membrane
Oxidoreductase
Proteomics identification
Reference proteome
Transmembrane
Transmembrane helix