Names & Taxonomy

Uniprot ID:
F5H2F4
Entry Name:
F5H2F4_HUMAN
Status:
unreviewed
Protein Names:
C-1-tetrahydrofolate synthase, cytoplasmic
Gene Names:
MTHFD1
Gene Names Primary:
MTHFD1
Organism:
Homo sapiens (Human)

Structure

Length:
1020
Sequence:
MRHRVCRGRSGQGRRRSSVIPWPVPKHVGWVVLLGCGGSGTSILVVSIVGSGLIKAMAPAEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEIGIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKDVDGLTSINAGKLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTAHLDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINYVPDDKKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAKRFLEKFKPGKWMIQYNNLNLKTPVPSDIDISRSCKPKPIGKLAREIGLLSEEVELYGETKAKVLLSALERLKHRPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLYQNVFACVRQPSQGPTFGIKGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLVPSVNGVRRFSDIQIRRLKRLGIEKTDPTTLTDEEINRFARLDIDPETITWQRVLDTNDRFLRKITIGQAPTEKGHTRTAQFDISVASEIMAVLALTTSLEDMRERLGKMVVASSKKGEPVSAEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVGPEGFVVTEAGFGADIGMEKFFNIKCRYSGLCPHVVVLVATVRALKMHGGGPTVTAGLPLPKAYIQENLELVEKGFSNLKKQIENARMFGIPVVVAVNAFKTDTESELDLISRLSREHGAFDAVKCTHWAEGGKGALALAQAVQRAAQAPSSFQLLYDLKLPVEDKIRIIAQKIYGADDIELLPEAQHKAEVYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFILPIRDIRASVGAGFLYPLVGTITIHLQEATLKVWPVSIQAHWELGSISKPREVSPCPEDLKLIVGVSPEVIFSLNSHHV
Proteomes:
UP000005640

Function

Gene Ontology Go:
ATP binding
formate-tetrahydrofolate ligase activity
methylenetetrahydrofolate dehydrogenase (NADP+) activity
folic acid-containing compound biosynthetic process
Gene Ontology Biological Process:
folic acid-containing compound biosynthetic process
Gene Ontology Molecular Function:
ATP binding
formate-tetrahydrofolate ligase activity
methylenetetrahydrofolate dehydrogenase (NADP+) activity
Keywords:
Complete proteome
Proteomics identification
Reference proteome

Publication

PubMed ID:
12508121 19413330 21269460 22223895 22814378 24275569 25944712