Names & Taxonomy
- Uniprot ID:
- A0A024RAP7
- Entry Name:
- A0A024RAP7_HUMAN
- Status:
- unreviewed
- Protein Names:
- Coagulation factor II (Thrombin) receptor, isoform CRA_a
- Gene Names:
- F2R hCG_37484
- Gene Names Orf:
- hCG_37484
- Gene Names Primary:
- F2R
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 425
- Sequence:
- MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
Function
- Gene Ontology Go:
- cytosol
integral component of membrane
thrombin receptor activity
blood coagulation
homeostasis of number of cells within a tissue
inflammatory response
negative regulation of renin secretion into blood stream
positive regulation of blood coagulation
positive regulation of cell migration
positive regulation of cytosolic calcium ion concentration
positive regulation of ERK1 and ERK2 cascade
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of Rho protein signal transduction
positive regulation of vasoconstriction
regulation of interleukin-1 beta production
response to lipopolysaccharide - Gene Ontology Biological Process:
- blood coagulation
homeostasis of number of cells within a tissue
inflammatory response
negative regulation of renin secretion into blood stream
positive regulation of blood coagulation
positive regulation of cell migration
positive regulation of cytosolic calcium ion concentration
positive regulation of ERK1 and ERK2 cascade
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of Rho protein signal transduction
positive regulation of vasoconstriction
regulation of interleukin-1 beta production
response to lipopolysaccharide - Gene Ontology Molecular Function:
- thrombin receptor activity
- Gene Ontology Cellular Component:
- cytosol
integral component of membrane - Keywords:
- G-protein coupled receptor
Membrane
Receptor
Signal
Transducer
Transmembrane
Transmembrane helix
Publication
- PubMed ID:
- 11181995