Names & Taxonomy
- Uniprot ID:
- A0A024RAD5
- Entry Name:
- A0A024RAD5_HUMAN
- Status:
- unreviewed
- Protein Names:
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (Oligosaccharyl transferase 48 kDa subunit) (EC 2.4.99.18)
- Gene Names:
- DDOST hCG_38871
- Gene Names Orf:
- hCG_38871
- Gene Names Primary:
- DDOST
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 456
- Sequence:
- MGYFRCAGAGSFGRRRKMEPSTAARAWALFWLLLPLLGAVCASGPRTLVLLDNLNVRETHSLFFRSLKDRGFELTFKTADDPSLSLIKYGEFLYDNLIIFSPSVEDFGGNINVETISAFIDGGGSVLVAASSDIGDPLRELGSECGIEFDEEKTAVIDHHNYDISDLGQHTLIVADTENLLKAPTIVGKSSLNPILFRGVGMVADPDNPLVLDILTGSSTSYSFFPDKPITQYPHAVGKNTLLIAGLQARNNARVIFSGSLDFFSDSFFNSAVQKAAPGSQRYSQTGNYELAVALSRWVFKEEGVLRVGPVSHHRVGETAPPNAYTVTDLVEYSIVIQQLSNGKWVPFDGDDIQLEFVRIDPFVRTFLKKKGGKYSVQFKLPDVYGVFQFKVDYNRLGYTHLYSSTQVSVRPLQHTQYERFIPSAYPYYASAFSMMLGLFIFSIVFLHMKEKEKSD
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.
- Pathway:
- Protein modification; protein glycosylation.
- Catalytic Activity:
- Dolichyl diphosphooligosaccharide + -L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine.
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
transferase activity, transferring glycosyl groups
protein N-linked glycosylation via asparagine - Gene Ontology Biological Process:
- protein N-linked glycosylation via asparagine
- Gene Ontology Molecular Function:
- transferase activity, transferring glycosyl groups
- Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane - Keywords:
- Endoplasmic reticulum
Glycosyltransferase
Membrane
Transferase
Transmembrane
Transmembrane helix
Publication
- PubMed ID:
- 11181995