Names & Taxonomy

Uniprot ID:
A0A024RAD5
Entry Name:
A0A024RAD5_HUMAN
Status:
unreviewed
Protein Names:
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (Oligosaccharyl transferase 48 kDa subunit) (EC 2.4.99.18)
Gene Names:
DDOST hCG_38871
Gene Names Orf:
hCG_38871
Gene Names Primary:
DDOST
Organism:
Homo sapiens (Human)

Structure

Length:
456
Sequence:
MGYFRCAGAGSFGRRRKMEPSTAARAWALFWLLLPLLGAVCASGPRTLVLLDNLNVRETHSLFFRSLKDRGFELTFKTADDPSLSLIKYGEFLYDNLIIFSPSVEDFGGNINVETISAFIDGGGSVLVAASSDIGDPLRELGSECGIEFDEEKTAVIDHHNYDISDLGQHTLIVADTENLLKAPTIVGKSSLNPILFRGVGMVADPDNPLVLDILTGSSTSYSFFPDKPITQYPHAVGKNTLLIAGLQARNNARVIFSGSLDFFSDSFFNSAVQKAAPGSQRYSQTGNYELAVALSRWVFKEEGVLRVGPVSHHRVGETAPPNAYTVTDLVEYSIVIQQLSNGKWVPFDGDDIQLEFVRIDPFVRTFLKKKGGKYSVQFKLPDVYGVFQFKVDYNRLGYTHLYSSTQVSVRPLQHTQYERFIPSAYPYYASAFSMMLGLFIFSIVFLHMKEKEKSD

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane

Function

Function:
Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.
Pathway:
Protein modification; protein glycosylation.
Catalytic Activity:
Dolichyl diphosphooligosaccharide + -L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine.
Gene Ontology Go:
endoplasmic reticulum membrane
integral component of membrane
transferase activity, transferring glycosyl groups
protein N-linked glycosylation via asparagine
Gene Ontology Biological Process:
protein N-linked glycosylation via asparagine
Gene Ontology Molecular Function:
transferase activity, transferring glycosyl groups
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
integral component of membrane
Keywords:
Endoplasmic reticulum
Glycosyltransferase
Membrane
Transferase
Transmembrane
Transmembrane helix

Publication

PubMed ID:
11181995