Names & Taxonomy
- Uniprot ID:
- A0A024R730
- Entry Name:
- A0A024R730_HUMAN
- Status:
- unreviewed
- Protein Names:
- Cystic fibrosis transmembrane conductance regulator (EC 3.6.3.49) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (cAMP-dependent chloride channel)
- Gene Names:
- CFTR hCG_15952
- Gene Names Orf:
- hCG_15952
- Gene Names Primary:
- CFTR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1480
- Sequence:
- MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASKKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQDTRL
Subcellular location
- Subcellular Location:
- Early endosome membrane
Function
- Function:
- Involved in the transport of chloride ions.
- Catalytic Activity:
- ATP + H(2)O = ADP + phosphate.
- Gene Ontology Go:
- apical plasma membrane
chloride channel complex
cytosol
early endosome membrane
ATP binding
bicarbonate transmembrane transporter activity
channel-conductance-controlling ATPase activity
cellular response to cAMP
cholesterol biosynthetic process
cholesterol transport
intracellular pH elevation
membrane hyperpolarization
positive regulation of cyclic nucleotide-gated ion channel activity
positive regulation of exocytosis
positive regulation of insulin secretion involved in cellular response to glucose stimulus
sperm capacitation
vesicle docking involved in exocytosis - Gene Ontology Biological Process:
- cellular response to cAMP
cholesterol biosynthetic process
cholesterol transport
intracellular pH elevation
membrane hyperpolarization
positive regulation of cyclic nucleotide-gated ion channel activity
positive regulation of exocytosis
positive regulation of insulin secretion involved in cellular response to glucose stimulus
sperm capacitation
vesicle docking involved in exocytosis - Gene Ontology Molecular Function:
- ATP binding
bicarbonate transmembrane transporter activity
channel-conductance-controlling ATPase activity - Gene Ontology Cellular Component:
- apical plasma membrane
chloride channel complex
cytosol
early endosome membrane - Keywords:
- ATP-binding
Chloride
Chloride channel
Hydrolase
Ion channel
Ion transport
Membrane
Nucleotide-binding
Phosphoprotein
Repeat
Transmembrane
Transmembrane helix
Transport
Publication
- PubMed ID:
- 11181995