Names & Taxonomy
- Uniprot ID:
- A8K7I4
- Entry Name:
- CLCA1_HUMAN
- Status:
- reviewed
- Protein Names:
- Calcium-activated chloride channel regulator 1 (EC 3.4.-.-) (Calcium-activated chloride channel family member 1) (hCLCA1) (Calcium-activated chloride channel protein 1) (CaCC-1) (hCaCC-1)
- Gene Names:
- CLCA1 CACC1
- Gene Names Primary:
- CLCA1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 914
- Sequence:
- MGPFKSSVFILILHLLEGALSNSLIQLNNNGYEGIVVAIDPNVPEDETLIQQIKDMVTQASLYLLEATGKRFYFKNVAILIPETWKTKADYVRPKLETYKNADVLVAESTPPGNDEPYTEQMGNCGEKGERIHLTPDFIAGKKLAEYGPQGRAFVHEWAHLRWGVFDEYNNDEKFYLSNGRIQAVRCSAGITGTNVVKKCQGGSCYTKRCTFNKVTGLYEKGCEFVLQSRQTEKASIMFAQHVDSIVEFCTEQNHNKEAPNKQNQKCNLRSTWEVIRDSEDFKKTTPMTTQPPNPTFSLLQIGQRIVCLVLDKSGSMATGNRLNRLNQAGQLFLLQTVELGSWVGMVTFDSAAHVQNELIQINSGSDRDTLAKRLPAAASGGTSICSGLRSAFTVIRKKYPTDGSEIVLLTDGEDNTISGCFNEVKQSGAIIHTVALGPSAAQELEELSKMTGGLQTYASDQVQNNGLIDAFGALSSGNGAVSQRSIQLESKGLTLQNSQWMNGTVIVDSTVGKDTLFLITWTMQPPQILLWDPSGQKQGGFVVDKNTKMAYLQIPGIAKVGTWKYSLQASSQTLTLTVTSRASNATLPPITVTSKTNKDTSKFPSPLVVYANIRQGASPILRASVTALIESVNGKTVTLELLDNGAGADATKDDGVYSRYFTTYDTNGRYSVKVRALGGVNAARRRVIPQQSGALYIPGWIENDEIQWNPPRPEINKDDVQHKQVCFSRTSSGGSFVASDVPNAPIPDLFPPGQITDLKAEIHGGSLINLTWTAPGDDYDHGTAHKYIIRISTSILDLRDKFNESLQVNTTALIPKEANSEEVFLFKPENITFENGTDLFIAIQAVDKVDLKSEISNIARVSLFIPPQTPPETPSPDETSAPCPNIHINSTIPGIHILKIMWKWIGELQLSIA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space
Function
- Function:
- May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
- Gene Ontology Go:
- extracellular space
integral component of plasma membrane
microvillus
plasma membrane
zymogen granule membrane
chloride channel activity
intracellular calcium activated chloride channel activity
metal ion binding
metallopeptidase activity
calcium ion transport
cellular response to hypoxia
chloride transmembrane transport
ion transmembrane transport
transmembrane transport
transport - Gene Ontology Biological Process:
- calcium ion transport
cellular response to hypoxia
chloride transmembrane transport
ion transmembrane transport
transmembrane transport
transport - Gene Ontology Molecular Function:
- chloride channel activity
intracellular calcium activated chloride channel activity
metal ion binding
metallopeptidase activity - Gene Ontology Cellular Component:
- extracellular space
integral component of plasma membrane
microvillus
plasma membrane
zymogen granule membrane - Keywords:
- Autocatalytic cleavage
Calcium
Calcium transport
Cell membrane
Chloride
Complete proteome
Direct protein sequencing
Glycoprotein
Hydrolase
Ion transport
Membrane
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Secreted
Signal
Transport
Zinc