Names & Taxonomy

Uniprot ID:
X5D2R1
Entry Name:
X5D2R1_HUMAN
Status:
unreviewed
Protein Names:
Tyrosine-protein kinase receptor (EC 2.7.10.1) (Fragment)
Gene Names:
NTRK3 hCG_26627
Gene Names Orf:
hCG_26627
Gene Names Primary:
NTRK3
Organism:
Homo sapiens (Human)

Structure

Length:
839
Sequence:
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG

Function

Catalytic Activity:
ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
Gene Ontology Go:
cytoplasm
integral component of plasma membrane
ATP binding
GPI-linked ephrin receptor activity
neurotrophin receptor activity
cellular response to retinoic acid
circadian rhythm
cochlea development
lens fiber cell differentiation
mechanoreceptor differentiation
modulation by virus of host transcription
negative regulation of astrocyte differentiation
negative regulation of cell death
neuron fate specification
neuron migration
positive regulation of apoptotic process
positive regulation of axon extension involved in regeneration
positive regulation of synapse assembly
protein autophosphorylation
response to axon injury
response to corticosterone
response to ethanol
Gene Ontology Biological Process:
cellular response to retinoic acid
circadian rhythm
cochlea development
lens fiber cell differentiation
mechanoreceptor differentiation
modulation by virus of host transcription
negative regulation of astrocyte differentiation
negative regulation of cell death
neuron fate specification
neuron migration
positive regulation of apoptotic process
positive regulation of axon extension involved in regeneration
positive regulation of synapse assembly
protein autophosphorylation
response to axon injury
response to corticosterone
response to ethanol
Gene Ontology Molecular Function:
ATP binding
GPI-linked ephrin receptor activity
neurotrophin receptor activity
Gene Ontology Cellular Component:
cytoplasm
integral component of plasma membrane
Keywords:
ATP-binding
Disulfide bond
Immunoglobulin domain
Kinase
Leucine-rich repeat
Membrane
Nucleotide-binding
Phosphoprotein
Receptor
Signal
Transferase
Transmembrane
Transmembrane helix
Tyrosine-protein kinase

Publication

PubMed ID:
11181995 24722188