Names & Taxonomy
- Uniprot ID:
- V9HWB7
- Entry Name:
- V9HWB7_HUMAN
- Status:
- unreviewed
- Protein Names:
- Aconitate hydratase (Aconitase) (EC 4.2.1.3)
- Gene Names:
- HEL60
- Gene Names Primary:
- HEL60
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 889
- Sequence:
- MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPADLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMIRKMAK
Function
- Function:
- Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
- Catalytic Activity:
- Citrate = isocitrate.
- Cofactor:
- COFACTOR: ; Note=Binds 1 cluster per subunit.
- Gene Ontology Go:
- cytoplasm
cytosol
mitochondrion
4 iron, 4 sulfur cluster binding
aconitate hydratase activity
iron-responsive element binding
cellular iron ion homeostasis
intestinal absorption
post-embryonic development
regulation of translation
response to iron(II) ion - Gene Ontology Biological Process:
- cellular iron ion homeostasis
intestinal absorption
post-embryonic development
regulation of translation
response to iron(II) ion - Gene Ontology Molecular Function:
- 4 iron, 4 sulfur cluster binding
aconitate hydratase activity
iron-responsive element binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
mitochondrion - Keywords:
- 4Fe-4S
Iron
Iron-sulfur
Lyase
Metal-binding