Names & Taxonomy

Uniprot ID:
V9HWB7
Entry Name:
V9HWB7_HUMAN
Status:
unreviewed
Protein Names:
Aconitate hydratase (Aconitase) (EC 4.2.1.3)
Gene Names:
HEL60
Gene Names Primary:
HEL60
Organism:
Homo sapiens (Human)

Structure

Length:
889
Sequence:
MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPADLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMIRKMAK

Function

Function:
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
Catalytic Activity:
Citrate = isocitrate.
Cofactor:
COFACTOR: ; Note=Binds 1 cluster per subunit.
Gene Ontology Go:
cytoplasm
cytosol
mitochondrion
4 iron, 4 sulfur cluster binding
aconitate hydratase activity
iron-responsive element binding
cellular iron ion homeostasis
intestinal absorption
post-embryonic development
regulation of translation
response to iron(II) ion
Gene Ontology Biological Process:
cellular iron ion homeostasis
intestinal absorption
post-embryonic development
regulation of translation
response to iron(II) ion
Gene Ontology Molecular Function:
4 iron, 4 sulfur cluster binding
aconitate hydratase activity
iron-responsive element binding
Gene Ontology Cellular Component:
cytoplasm
cytosol
mitochondrion
Keywords:
4Fe-4S
Iron
Iron-sulfur
Lyase
Metal-binding