Names & Taxonomy

Uniprot ID:
U5YWV7
Entry Name:
U5YWV7_HUMAN
Status:
unreviewed
Protein Names:
Cytochrome c oxidase subunit 1 (EC 1.9.3.1)
Gene Names:
COX1 CO1 COI
Gene Names Primary:
COX1
Organism:
Homo sapiens (Human)

Structure

Length:
513
Sequence:
MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEPVYMKS

Subcellular location

Subcellular Location:
Mitochondrion inner membrane
Gene Encoded:
Mitochondrion

Function

Function:
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
Pathway:
Energy metabolism; oxidative phosphorylation.
Catalytic Activity:
4 ferrocytochrome c + O(2) + 4 H(+) = 4 ferricytochrome c + 2 H(2)O.
Gene Ontology Go:
integral component of membrane
mitochondrial respiratory chain complex IV
cytochrome-c oxidase activity
heme binding
iron ion binding
aerobic respiration
aging
cerebellum development
oxidative phosphorylation
response to copper ion
response to electrical stimulus
response to oxidative stress
Gene Ontology Biological Process:
aerobic respiration
aging
cerebellum development
oxidative phosphorylation
response to copper ion
response to electrical stimulus
response to oxidative stress
Gene Ontology Molecular Function:
cytochrome-c oxidase activity
heme binding
iron ion binding
Gene Ontology Cellular Component:
integral component of membrane
mitochondrial respiratory chain complex IV
Keywords:
Copper
Electron transport
Heme
Iron
Membrane
Metal-binding
Mitochondrion
Mitochondrion inner membrane
Oxidoreductase
Respiratory chain
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
24323467 24143169 24244704 24114781 24341918 25130626 24607387 24726474 25418795 24621318 25301575 24884847 24713204 25303789 24986921 25219341 25254093 25100861 25463651 25457022 25032828 25299580 24498190 24676463 24901532 25757516 25887241 25564040 26242992 26416320 26188410 25832481 26428318 25731774 25738654 26061688 26053380 26263179 26262956 26509580 26509686 26640946 26504230 25669617 25826227 26211407 26434580 26538459 25908660 26781090 26875094