Names & Taxonomy
- Uniprot ID:
- Q9Y6Y9
- Entry Name:
- LY96_HUMAN
- Status:
- reviewed
- Protein Names:
- Lymphocyte antigen 96 (Ly-96) (ESOP-1) (Protein MD-2)
- Gene Names:
- LY96 ESOP1 MD2
- Gene Names Primary:
- LY96
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 160
- Sequence:
- MLPFLFFSTLFSSIFTEAQKQYWVCNSSDASISYTYCDKMQYPISINVNPCIELKRSKGLLHIFYIPRRDLKQLYFNLYITVNTMNLPKRKEVICRGSDDDYSFCRALKGETVNTTISFSFKGIKFSKGKYKCVVEAISGSPEEMLFCLEFVILHQPNSN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space
Function
- Function:
- Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581).
- Gene Ontology Go:
- endosome membrane
extracellular space
intrinsic component of plasma membrane
lipopolysaccharide receptor complex
plasma membrane
coreceptor activity
lipopolysaccharide receptor activity
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
apoptotic process
cell surface receptor signaling pathway
cellular defense response
detection of lipopolysaccharide
extrinsic apoptotic signaling pathway
I-kappaB kinase/NF-kappaB signaling
inflammatory response
innate immune response
MyD88-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
positive regulation of lipopolysaccharide-mediated signaling pathway
positive regulation of tumor necrosis factor production
programmed cell death
response to lipopolysaccharide
toll-like receptor 2 signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
toll-like receptor signaling pathway
toll-like receptor TLR1:TLR2 signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway
TRIF-dependent toll-like receptor signaling pathway - Gene Ontology Biological Process:
- activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
apoptotic process
cell surface receptor signaling pathway
cellular defense response
detection of lipopolysaccharide
extrinsic apoptotic signaling pathway
I-kappaB kinase/NF-kappaB signaling
inflammatory response
innate immune response
MyD88-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
positive regulation of lipopolysaccharide-mediated signaling pathway
positive regulation of tumor necrosis factor production
programmed cell death
response to lipopolysaccharide
toll-like receptor 2 signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
toll-like receptor signaling pathway
toll-like receptor TLR1:TLR2 signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway
TRIF-dependent toll-like receptor signaling pathway - Gene Ontology Molecular Function:
- coreceptor activity
lipopolysaccharide receptor activity - Gene Ontology Cellular Component:
- endosome membrane
extracellular space
intrinsic component of plasma membrane
lipopolysaccharide receptor complex
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Disulfide bond
Glycoprotein
Immunity
Inflammatory response
Innate immunity
Polymorphism
Reference proteome
Secreted
Signal - Interacts With:
- O00206