Names & Taxonomy

Uniprot ID:
Q9Y6L6
Entry Name:
SO1B1_HUMAN
Status:
reviewed
Protein Names:
Solute carrier organic anion transporter family member 1B1 (Liver-specific organic anion transporter 1) (LST-1) (OATP-C) (Sodium-independent organic anion-transporting polypeptide 2) (OATP-2) (Solute carrier family 21 member 6)
Gene Names:
SLCO1B1 LST1 OATP1B1 OATP2 OATPC SLC21A6
Gene Names Primary:
SLCO1B1
Organism:
Homo sapiens (Human)

Structure

Length:
691
Sequence:
MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGYYRYSKETNINSSENSTSTLSTCLINQILSLNRASPEIVGKGCLKESGSYMWIYVFMGNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQTPNKPQKERKASLSLHVLETNDEKDQTANLTNQGKNITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYFFILCENKSVAGLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGITYISPCLAGCKSSSGNKKPIVFYNCSCLEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCIKWSTNNCGTRGSCRTYNSTSFSRVYLGLSSMLRVSSLVLYIILIYAMKKKYQEKDINASENGSVMDEANLESLNKNKHFVPSAGADSETHC
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Basolateral cell membrane

Function

Function:
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.
Cross Reference Drug Bank:
DB06151 DB06403 DB00345 DB01076 DB06626 DB01053 DB01393 DB06772 DB00520 DB02659 DB01211 DB05239 DB00286 DB00091 DB08912 DB09102 DB00509 DB00390 DB00917 DB06210 DB09272 DB00783 DB00655 DB00973 DB00950 DB01095 DB08884 DB01241 DB09054 DB00224 DB00762 DB00583 DB00451 DB00279 DB01583 DB00227 DB00563 DB00688 DB00220 DB00275 DB01092 DB00213 DB06589 DB00859 DB01132 DB08860 DB00175 DB00908 DB00912 DB01045 DB08864 DB00503 DB00412 DB01098 DB09292 DB01232 DB11362 DB06290 DB00641 DB00877 DB00669 DB00177 DB00661
Gene Ontology Go:
basolateral plasma membrane
integral component of plasma membrane
membrane
plasma membrane
bile acid transmembrane transporter activity
sodium-independent organic anion transmembrane transporter activity
bile acid and bile salt transport
bile acid metabolic process
organic anion transport
small molecule metabolic process
sodium-independent organic anion transport
transmembrane transport
Gene Ontology Biological Process:
bile acid and bile salt transport
bile acid metabolic process
organic anion transport
small molecule metabolic process
sodium-independent organic anion transport
transmembrane transport
Gene Ontology Molecular Function:
bile acid transmembrane transporter activity
sodium-independent organic anion transmembrane transporter activity
Gene Ontology Cellular Component:
basolateral plasma membrane
integral component of plasma membrane
membrane
plasma membrane
Keywords:
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
10358072 10601278 10644574 10779507 14702039 15489334 22232210 23285087 24275569 11477075 12196548 12130747