Names & Taxonomy
- Uniprot ID:
- Q9Y6I3
- Entry Name:
- EPN1_HUMAN
- Status:
- reviewed
- Protein Names:
- Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1)
- Gene Names:
- EPN1
- Gene Names Primary:
- EPN1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 576
- Sequence:
- MSTSSLRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQGVNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQSSGEEELQLQLALAMSKEEADQPPSCGPEDDAQLQLALSLSREEHDKEERIRRGDDLRLQMAIEESKRETGGKEESSLMDLADVFTAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYISPLGGGPGLPPMMPPGPPAPNTNPFLL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis.
- Gene Ontology Go:
- coated pit
cytoplasm
nucleus
plasma membrane
lipid binding
embryonic organ development
endocytosis
epidermal growth factor receptor signaling pathway
female pregnancy
in utero embryonic development
negative regulation of epidermal growth factor receptor signaling pathway
Notch signaling pathway - Gene Ontology Biological Process:
- embryonic organ development
endocytosis
epidermal growth factor receptor signaling pathway
female pregnancy
in utero embryonic development
negative regulation of epidermal growth factor receptor signaling pathway
Notch signaling pathway - Gene Ontology Molecular Function:
- lipid binding
- Gene Ontology Cellular Component:
- coated pit
cytoplasm
nucleus
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Coated pit
Complete proteome
Cytoplasm
Endocytosis
Lipid-binding
Membrane
Nucleus
Phosphoprotein
Reference proteome
Repeat
Ubl conjugation - Interacts With:
- Q15038; Q96CS7