Names & Taxonomy

Uniprot ID:
Q9Y698
Entry Name:
CCG2_HUMAN
Status:
reviewed
Protein Names:
Voltage-dependent calcium channel gamma-2 subunit (Neuronal voltage-gated calcium channel gamma-2 subunit) (Transmembrane AMPAR regulatory protein gamma-2) (TARP gamma-2)
Gene Names:
CACNG2
Gene Names Primary:
CACNG2
Organism:
Homo sapiens (Human)

Structure

Length:
323
Sequence:
MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTHSGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGLCIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQASAITRIPSYRYRYQRRSRSSSRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKAATTPTATYNSDRDNSFLQVHNCIQKENKDSLHSNTANRRTTPV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Multi-pass membrane protein.

Function

Function:
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.
Cross Reference Drug Bank:
DB00898
Gene Ontology Go:
AMPA glutamate receptor complex
endocytic vesicle membrane
plasma membrane
voltage-gated calcium channel complex
channel regulator activity
voltage-gated calcium channel activity
cardiac conduction
membrane depolarization
membrane hyperpolarization
neuromuscular junction development
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
synaptic transmission
transmission of nerve impulse
transport
Gene Ontology Biological Process:
cardiac conduction
membrane depolarization
membrane hyperpolarization
neuromuscular junction development
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
synaptic transmission
transmission of nerve impulse
transport
Gene Ontology Molecular Function:
channel regulator activity
voltage-gated calcium channel activity
Gene Ontology Cellular Component:
AMPA glutamate receptor complex
endocytic vesicle membrane
plasma membrane
voltage-gated calcium channel complex
Keywords:
Calcium
Calcium channel
Calcium transport
Complete proteome
Disease mutation
Glycoprotein
Ion channel
Ion transport
Membrane
Mental retardation
Phosphoprotein
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel

Publication

PubMed ID:
10221464 15461802 10591208 15489334 20805473 21376300