Names & Taxonomy
- Uniprot ID:
- Q9Y698
- Entry Name:
- CCG2_HUMAN
- Status:
- reviewed
- Protein Names:
- Voltage-dependent calcium channel gamma-2 subunit (Neuronal voltage-gated calcium channel gamma-2 subunit) (Transmembrane AMPAR regulatory protein gamma-2) (TARP gamma-2)
- Gene Names:
- CACNG2
- Gene Names Primary:
- CACNG2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 323
- Sequence:
- MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTHSGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGLCIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQASAITRIPSYRYRYQRRSRSSSRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKAATTPTATYNSDRDNSFLQVHNCIQKENKDSLHSNTANRRTTPV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.
- Cross Reference Drug Bank:
- DB00898
- Gene Ontology Go:
- AMPA glutamate receptor complex
endocytic vesicle membrane
plasma membrane
voltage-gated calcium channel complex
channel regulator activity
voltage-gated calcium channel activity
cardiac conduction
membrane depolarization
membrane hyperpolarization
neuromuscular junction development
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
synaptic transmission
transmission of nerve impulse
transport - Gene Ontology Biological Process:
- cardiac conduction
membrane depolarization
membrane hyperpolarization
neuromuscular junction development
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
synaptic transmission
transmission of nerve impulse
transport - Gene Ontology Molecular Function:
- channel regulator activity
voltage-gated calcium channel activity - Gene Ontology Cellular Component:
- AMPA glutamate receptor complex
endocytic vesicle membrane
plasma membrane
voltage-gated calcium channel complex - Keywords:
- Calcium
Calcium channel
Calcium transport
Complete proteome
Disease mutation
Glycoprotein
Ion channel
Ion transport
Membrane
Mental retardation
Phosphoprotein
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel