Names & Taxonomy
- Uniprot ID:
- Q9Y5Z0
- Entry Name:
- BACE2_HUMAN
- Status:
- reviewed
- Protein Names:
- Beta-secretase 2 (EC 3.4.23.45) (Aspartic-like protease 56 kDa) (Aspartyl protease 1) (ASP1) (Asp 1) (Beta-site amyloid precursor protein cleaving enzyme 2) (Beta-site APP cleaving enzyme 2) (Down region aspartic protease) (DRAP) (Memapsin-1) (Membrane-associated aspartic protease 1) (Theta-secretase)
- Gene Names:
- BACE2 AEPLC ALP56 ASP21 CDA13 UNQ418/PRO852
- Gene Names Orf:
- CDA13 UNQ418/PRO852
- Gene Names Primary:
- BACE2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 518
- Sequence:
- MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein. Golgi apparatus. Endoplasmic reticulum. Endosome. Cell surface.
Function
- Function:
- Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
- Catalytic Activity:
- Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein.
- Active Site:
- ACT_SITE 110 110; ACT_SITE 303 303
- Gene Ontology Go:
- cell surface
endoplasmic reticulum
endosome
Golgi apparatus
integral component of membrane
aspartic-type endopeptidase activity
beta-amyloid binding
beta-amyloid metabolic process
membrane protein ectodomain proteolysis
negative regulation of amyloid precursor protein biosynthetic process
peptide hormone processing
protein catabolic process
proteolysis - Gene Ontology Biological Process:
- beta-amyloid metabolic process
membrane protein ectodomain proteolysis
negative regulation of amyloid precursor protein biosynthetic process
peptide hormone processing
protein catabolic process
proteolysis - Gene Ontology Molecular Function:
- aspartic-type endopeptidase activity
beta-amyloid binding - Gene Ontology Cellular Component:
- cell surface
endoplasmic reticulum
endosome
Golgi apparatus
integral component of membrane - Keywords:
- 3D-structure
Alternative splicing
Aspartyl protease
Autocatalytic cleavage
Complete proteome
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Endosome
Glycoprotein
Golgi apparatus
Hydrolase
Membrane
Protease
Reference proteome
Signal
Transmembrane
Transmembrane helix
Zymogen