Names & Taxonomy

Uniprot ID:
Q9Y5Y4
Entry Name:
PD2R2_HUMAN
Status:
reviewed
Protein Names:
Prostaglandin D2 receptor 2 (Chemoattractant receptor-homologous molecule expressed on Th2 cells) (G-protein coupled receptor 44) (CD antigen CD294)
Gene Names:
PTGDR2 CRTH2 DL1R GPR44
Gene Names Primary:
PTGDR2
Organism:
Homo sapiens (Human)

Structure

Length:
395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
Cross Reference Drug Bank:
DB00328 DB00605
Gene Ontology Go:
integral component of plasma membrane
intracellular
neuron projection
plasma membrane
G-protein coupled receptor activity
neuropeptide binding
prostaglandin D receptor activity
prostaglandin F receptor activity
prostaglandin J receptor activity
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
calcium-mediated signaling
chemotaxis
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
immune response
negative regulation of male germ cell proliferation
neuropeptide signaling pathway
positive regulation of G-protein coupled receptor protein signaling pathway
synaptic transmission
Gene Ontology Biological Process:
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
calcium-mediated signaling
chemotaxis
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
immune response
negative regulation of male germ cell proliferation
neuropeptide signaling pathway
positive regulation of G-protein coupled receptor protein signaling pathway
synaptic transmission
Gene Ontology Molecular Function:
G-protein coupled receptor activity
neuropeptide binding
prostaglandin D receptor activity
prostaglandin F receptor activity
prostaglandin J receptor activity
Gene Ontology Cellular Component:
integral component of plasma membrane
intracellular
neuron projection
plasma membrane
Keywords:
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix

Publication

PubMed ID:
10036181 9973380 16554811 15489334 11535533 11168006 11208866 12466225 17196174 17207480 20035740