Names & Taxonomy
- Uniprot ID:
- Q9Y5R2
- Entry Name:
- MMP24_HUMAN
- Status:
- reviewed
- Protein Names:
- Matrix metalloproteinase-24 (MMP-24) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (MTMMP5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP) (MT5MMP) [Cleaved into: Processed matrix metalloproteinase-24]
- Gene Names:
- MMP24 MT5MMP
- Gene Names Primary:
- MMP24
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 645
- Sequence:
- MPRSRGGRAAPGPPPPPPPPGQAPRWSRWRVPGRLLLLLLPALCCLPGAARAAAAAAGAGNRAAVAVAVARADEAEAPFAGQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTPGTKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMGCNQKEVERRKERRLPQDDVDIMVTINDVPGSVNAVAVVIPCILSLCILVLVYTIFQFKNKTGPQPVTYYKRPVQEWV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Matrix metalloproteinase-24: Cell membrane
Function
- Function:
- Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity).
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 283 283
- Cross Reference Drug Bank:
- DB00786
- Gene Ontology Go:
- extracellular exosome
integral component of plasma membrane
proteinaceous extracellular matrix
trans-Golgi network membrane
calcium ion binding
enzyme activator activity
metalloendopeptidase activity
zinc ion binding
cell-cell adhesion
cell-cell adhesion mediated by cadherin
detection of temperature stimulus involved in sensory perception of pain
glial cell differentiation
neuronal stem cell population maintenance
positive regulation of catalytic activity
proteolysis - Gene Ontology Biological Process:
- cell-cell adhesion
cell-cell adhesion mediated by cadherin
detection of temperature stimulus involved in sensory perception of pain
glial cell differentiation
neuronal stem cell population maintenance
positive regulation of catalytic activity
proteolysis - Gene Ontology Molecular Function:
- calcium ion binding
enzyme activator activity
metalloendopeptidase activity
zinc ion binding - Gene Ontology Cellular Component:
- extracellular exosome
integral component of plasma membrane
proteinaceous extracellular matrix
trans-Golgi network membrane - Keywords:
- Calcium
Cell adhesion
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Disulfide bond
Extracellular matrix
Golgi apparatus
Hydrolase
Membrane
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Repeat
Secreted
Signal
Transmembrane
Transmembrane helix
Zinc
Zymogen