Names & Taxonomy
- Uniprot ID:
- Q9Y468
- Entry Name:
- LMBL1_HUMAN
- Status:
- reviewed
- Protein Names:
- Lethal(3)malignant brain tumor-like protein 1 (H-l(3)mbt) (H-l(3)mbt protein) (L(3)mbt-like) (L(3)mbt protein homolog) (L3MBTL1)
- Gene Names:
- L3MBTL1 KIAA0681 L3MBT L3MBTL
- Gene Names Primary:
- L3MBTL1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 752
- Sequence:
- MRRREGHGTDSEMGQGPVRESQSSDPPALQFRISEYKPLNMAGVEQPPSPELRQEGVTEYEDGGAPAGDGEAGPQQAEDHPQNPPEDPNQDPPEDDSTCQCQACGPHQAAGPDLGSSNDGCPQLFQERSVIVENSSGSTSASELLKPMKKRKRREYQSPSEEESEPEAMEKQEEGKDPEGQPTASTPESEEWSSSQPATGEKKECWSWESYLEEQKAITAPVSLFQDSQAVTHNKNGFKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQPPKGYKEEEFSWSQYLRSTRAQAAPKHLFVSQSHSPPPLGFQVGMKLEAVDRMNPSLVCVASVTDVVDSRFLVHFDNWDDTYDYWCDPSSPYIHPVGWCQKQGKPLTPPQDYPDPDNFCWEKYLEETGASAVPTWAFKVRPPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDADHPDIHPAGWCSKTGHPLQPPLGPREPSSASPGGCPPLSYRSLPHTRTSKYSFHHRKCPTPGCDGSGHVTGKFTAHHCLSGCPLAERNQSRLKAELSDSEASARKKNLSGFSPRKKPRHHGRIGRPPKYRKIPQEDFQTLTPDVVHQSLFMSALSAHPDRSLSVCWEQHCKLLPGVAGISASTVAKWTIDEVFGFVQTLTGCEDQARLFKDEMIDGEAFLLLTQADIVKIMSVKLGPALKIYNAILMFKNADDTLK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.
- Gene Ontology Go:
- chromatin
condensed chromosome
nucleoplasm
nucleus
plasma membrane
chromatin binding
histone binding
identical protein binding
methylated histone binding
nucleosomal histone binding
nucleosome binding
SAM domain binding
transcription factor activity, sequence-specific DNA binding
zinc ion binding
chromatin modification
hemopoiesis
negative regulation of transcription, DNA-templated
regulation of cell cycle
regulation of megakaryocyte differentiation
regulation of mitotic nuclear division
transcription, DNA-templated - Gene Ontology Biological Process:
- chromatin modification
hemopoiesis
negative regulation of transcription, DNA-templated
regulation of cell cycle
regulation of megakaryocyte differentiation
regulation of mitotic nuclear division
transcription, DNA-templated - Gene Ontology Molecular Function:
- chromatin binding
histone binding
identical protein binding
methylated histone binding
nucleosomal histone binding
nucleosome binding
SAM domain binding
transcription factor activity, sequence-specific DNA binding
zinc ion binding - Gene Ontology Cellular Component:
- chromatin
condensed chromosome
nucleoplasm
nucleus
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Chromatin regulator
Complete proteome
Metal-binding
Nucleus
Polymorphism
Reference proteome
Repeat
Repressor
Transcription
Transcription regulation
Ubl conjugation
Zinc
Zinc-finger - Interacts With:
- P10412; P68431; P62805