Names & Taxonomy
- Uniprot ID:
- Q9Y3Q0
- Entry Name:
- NALD2_HUMAN
- Status:
- reviewed
- Protein Names:
- N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase III) (GCPIII) (N-acetylated-alpha-linked acidic dipeptidase II) (NAALADase II)
- Gene Names:
- NAALAD2
- Gene Names Primary:
- NAALAD2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 740
- Sequence:
- MAESRGRLYLWMCLAAALASFLMGFMVGWFIKPLKETTTSVRYHQSIRWKLVSEMKAENIKSFLRSFTKLPHLAGTEQNFLLAKKIQTQWKKFGLDSAKLVHYDVLLSYPNETNANYISIVDEHETEIFKTSYLEPPPDGYENVTNIVPPYNAFSAQGMPEGDLVYVNYARTEDFFKLEREMGINCTGKIVIARYGKIFRGNKVKNAMLAGAIGIILYSDPADYFAPEVQPYPKGWNLPGTAAQRGNVLNLNGAGDPLTPGYPAKEYTFRLDVEEGVGIPRIPVHPIGYNDAEILLRYLGGIAPPDKSWKGALNVSYSIGPGFTGSDSFRKVRMHVYNINKITRIYNVVGTIRGSVEPDRYVILGGHRDSWVFGAIDPTSGVAVLQEIARSFGKLMSKGWRPRRTIIFASWDAEEFGLLGSTEWAEENVKILQERSIAYINSDSSIEGNYTLRVDCTPLLYQLVYKLTKEIPSPDDGFESKSLYESWLEKDPSPENKNLPRINKLGSGSDFEAYFQRLGIASGRARYTKNKKTDKYSSYPVYHTIYETFELVEKFYDPTFKKQLSVAQLRGALVYELVDSKIIPFNIQDYAEALKNYAASIYNLSKKHDQQLTDHGVSFDSLFSAVKNFSEAASDFHKRLIQVDLNNPIAVRMMNDQLMLLERAFIDPLGLPGKLFYRHIIFAPSSHNKYAGESFPGIYDAIFDIENKANSRLAWKEVKKHISIAAFTIQAAAGTLKEVL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivate the peptide neurotransmitter N-acetylaspartylglutamate.
- Catalytic Activity:
- Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by quisqualate.
- Active Site:
- ACT_SITE 414 414 Nucleophile; for NAALADase activity.
- Gene Ontology Go:
- integral component of membrane
plasma membrane
carboxypeptidase activity
dipeptidase activity
dipeptidyl-peptidase activity
metal ion binding
metallopeptidase activity
N-formylglutamate deformylase activity
serine-type peptidase activity
cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
neurotransmitter catabolic process
proteolysis
small molecule metabolic process - Gene Ontology Biological Process:
- cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
neurotransmitter catabolic process
proteolysis
small molecule metabolic process - Gene Ontology Molecular Function:
- carboxypeptidase activity
dipeptidase activity
dipeptidyl-peptidase activity
metal ion binding
metallopeptidase activity
N-formylglutamate deformylase activity
serine-type peptidase activity - Gene Ontology Cellular Component:
- integral component of membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Calcium
Carboxypeptidase
Cell membrane
Complete proteome
Dipeptidase
Glycoprotein
Hydrolase
Membrane
Metal-binding
Metalloprotease
Multifunctional enzyme
Polymorphism
Protease
Reference proteome
Signal-anchor
Transmembrane
Transmembrane helix
Zinc