Names & Taxonomy

Uniprot ID:
Q9Y3Q0
Entry Name:
NALD2_HUMAN
Status:
reviewed
Protein Names:
N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase III) (GCPIII) (N-acetylated-alpha-linked acidic dipeptidase II) (NAALADase II)
Gene Names:
NAALAD2
Gene Names Primary:
NAALAD2
Organism:
Homo sapiens (Human)

Structure

Length:
740
Sequence:
MAESRGRLYLWMCLAAALASFLMGFMVGWFIKPLKETTTSVRYHQSIRWKLVSEMKAENIKSFLRSFTKLPHLAGTEQNFLLAKKIQTQWKKFGLDSAKLVHYDVLLSYPNETNANYISIVDEHETEIFKTSYLEPPPDGYENVTNIVPPYNAFSAQGMPEGDLVYVNYARTEDFFKLEREMGINCTGKIVIARYGKIFRGNKVKNAMLAGAIGIILYSDPADYFAPEVQPYPKGWNLPGTAAQRGNVLNLNGAGDPLTPGYPAKEYTFRLDVEEGVGIPRIPVHPIGYNDAEILLRYLGGIAPPDKSWKGALNVSYSIGPGFTGSDSFRKVRMHVYNINKITRIYNVVGTIRGSVEPDRYVILGGHRDSWVFGAIDPTSGVAVLQEIARSFGKLMSKGWRPRRTIIFASWDAEEFGLLGSTEWAEENVKILQERSIAYINSDSSIEGNYTLRVDCTPLLYQLVYKLTKEIPSPDDGFESKSLYESWLEKDPSPENKNLPRINKLGSGSDFEAYFQRLGIASGRARYTKNKKTDKYSSYPVYHTIYETFELVEKFYDPTFKKQLSVAQLRGALVYELVDSKIIPFNIQDYAEALKNYAASIYNLSKKHDQQLTDHGVSFDSLFSAVKNFSEAASDFHKRLIQVDLNNPIAVRMMNDQLMLLERAFIDPLGLPGKLFYRHIIFAPSSHNKYAGESFPGIYDAIFDIENKANSRLAWKEVKKHISIAAFTIQAAAGTLKEVL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivate the peptide neurotransmitter N-acetylaspartylglutamate.
Catalytic Activity:
Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates.
Cofactor:
COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Enzyme Regulation:
ENZYME REGULATION: Inhibited by quisqualate.
Active Site:
ACT_SITE 414 414 Nucleophile; for NAALADase activity.
Gene Ontology Go:
integral component of membrane
plasma membrane
carboxypeptidase activity
dipeptidase activity
dipeptidyl-peptidase activity
metal ion binding
metallopeptidase activity
N-formylglutamate deformylase activity
serine-type peptidase activity
cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
neurotransmitter catabolic process
proteolysis
small molecule metabolic process
Gene Ontology Biological Process:
cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
neurotransmitter catabolic process
proteolysis
small molecule metabolic process
Gene Ontology Molecular Function:
carboxypeptidase activity
dipeptidase activity
dipeptidyl-peptidase activity
metal ion binding
metallopeptidase activity
N-formylglutamate deformylase activity
serine-type peptidase activity
Gene Ontology Cellular Component:
integral component of membrane
plasma membrane
Keywords:
3D-structure
Alternative splicing
Calcium
Carboxypeptidase
Cell membrane
Complete proteome
Dipeptidase
Glycoprotein
Hydrolase
Membrane
Metal-binding
Metalloprotease
Multifunctional enzyme
Polymorphism
Protease
Reference proteome
Signal-anchor
Transmembrane
Transmembrane helix
Zinc

Publication

PubMed ID:
10085079 16303743 16554811 15489334 19678840