Names & Taxonomy
- Uniprot ID:
- Q9Y3D2
- Entry Name:
- MSRB2_HUMAN
- Status:
- reviewed
- Protein Names:
- Methionine-R-sulfoxide reductase B2, mitochondrial (MsrB2) (EC 1.8.4.-)
- Gene Names:
- MSRB2 CBS-1 MSRB CGI-131
- Gene Names Orf:
- CGI-131
- Gene Names Primary:
- MSRB2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 182
- Sequence:
- MARLLWLLRGLTLGTAPRRAVRGQAGGGGPGTGPGLGEAGSLATCELPLAKSEWQKKLTPEQFYVTREKGTEPPFSGIYLNNKEAGMYHCVCCDSPLFSSEKKYCSGTGWPSFSEAHGTSGSDESHTGILRRLDTSLGSARTEVVCKQCEAHLGHVFPDGPGPNGQRFCINSVALKFKPRKH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion
Function
- Function:
- Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance.
- Catalytic Activity:
- L-methionine + oxidized thioredoxin = L-methionine R-oxide + reduced thioredoxin.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 169 169 Nucleophile.
- Cross Reference Drug Bank:
- DB00134
- Gene Ontology Go:
- cytosol
mitochondrion
actin binding
peptide-methionine (R)-S-oxide reductase activity
transcription factor activity, sequence-specific DNA binding
zinc ion binding
actin filament polymerization
cellular protein metabolic process
protein repair
regulation of transcription, DNA-templated
response to oxidative stress - Gene Ontology Biological Process:
- actin filament polymerization
cellular protein metabolic process
protein repair
regulation of transcription, DNA-templated
response to oxidative stress - Gene Ontology Molecular Function:
- actin binding
peptide-methionine (R)-S-oxide reductase activity
transcription factor activity, sequence-specific DNA binding
zinc ion binding - Gene Ontology Cellular Component:
- cytosol
mitochondrion - Keywords:
- Complete proteome
Metal-binding
Mitochondrion
Oxidoreductase
Polymorphism
Reference proteome
Transit peptide
Zinc