Names & Taxonomy

Uniprot ID:
Q9Y2D0
Entry Name:
CAH5B_HUMAN
Status:
reviewed
Protein Names:
Carbonic anhydrase 5B, mitochondrial (EC 4.2.1.1) (Carbonate dehydratase VB) (Carbonic anhydrase VB) (CA-VB)
Gene Names:
CA5B
Gene Names Primary:
CA5B
Organism:
Homo sapiens (Human)

Structure

Length:
317
Sequence:
MVVMNSLRVILQASPGKLLWRKFQIPRFMPARPCSLYTCTYKTRNRALHPLWESVDLVPGGDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHVWNNGYSFLVEFEDSTDKSVIKGGPLEHNYRLKQFHFHWGAIDAWGSEHTVDSKCFPAELHLVHWNAVRFENFEDAALEENGLAVIGVFLKLGKHHKELQKLVDTLPSIKHKDALVEFGSFDPSCLMPTCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSFRHDYVLNVQAKPKPATSQATP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion.

Function

Function:
Reversible hydration of carbon dioxide.
Catalytic Activity:
H(2)CO(3) = CO(2) + H(2)O.
Cofactor:
COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Enzyme Regulation:
ENZYME REGULATION: Inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), saccharin and Foscarnet (phosphonoformate trisodium salt).
Cross Reference Drug Bank:
DB00909
Gene Ontology Go:
mitochondrial matrix
mitochondrion
carbonate dehydratase activity
zinc ion binding
bicarbonate transport
one-carbon metabolic process
small molecule metabolic process
Gene Ontology Biological Process:
bicarbonate transport
one-carbon metabolic process
small molecule metabolic process
Gene Ontology Molecular Function:
carbonate dehydratase activity
zinc ion binding
Gene Ontology Cellular Component:
mitochondrial matrix
mitochondrion
Keywords:
Complete proteome
Lyase
Metal-binding
Mitochondrion
Reference proteome
Transit peptide
Zinc

Publication

PubMed ID:
10409679 14702039 15489334 17705204 17314045 19186056 19206230