Names & Taxonomy
- Uniprot ID:
- Q9Y2C5
- Entry Name:
- S17A4_HUMAN
- Status:
- reviewed
- Protein Names:
- Probable small intestine urate exporter (Solute carrier family 17 member 4)
- Gene Names:
- SLC17A4
- Gene Names Primary:
- SLC17A4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 497
- Sequence:
- MSTGPDVKATVGDISSDGNLNVAQEECSRKGFCSVRHGLALILQLCNFSIYTQQMNLSIAIPAMVNNTAPPSQPNASTERPSTDSQGYWNETLKEFKAMAPAYDWSPEIQGIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANAGVALLIVLRIVQGIAQVMVLTGQYSIWVKWAPPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFYIFGGIGCACCPLWFPLIYDDPVNHPFISAGEKRYIVCSLAQQDCSPGWSLPIRAMIKSLPLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALPFVVGCICIILGGLLADFLLSRKILRLITIRKLFTAIGVLFPSVILVSLPWVRSSHSMTMTFLVLSSAISSFCESGALVNFLDIAPRYTGFLKGLLQVFAHIAGAISPTAAGFFISQDSEFGWRNVFLLSAAVNISGLVFYLIFGRADVQDWAKEQTFTHL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Apical cell membrane
Function
- Function:
- Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions. May be involved in urate extrusion from the intestinal duct. May recognize hydrophilic anionic drugs such as aspirin, salicylate, and ibuprofen as substrates. Able to actively transport inorganic phosphate into cells via Na(+) cotransport (in vitro).
- Gene Ontology Go:
- apical plasma membrane
integral component of plasma membrane
membrane
sodium-dependent phosphate transmembrane transporter activity
sodium:phosphate symporter activity
phosphate ion transmembrane transport
phosphate-containing compound metabolic process
sodium ion transmembrane transport
sodium ion transport
sodium-dependent phosphate transport - Gene Ontology Biological Process:
- phosphate-containing compound metabolic process
phosphate ion transmembrane transport
sodium-dependent phosphate transport
sodium ion transmembrane transport
sodium ion transport - Gene Ontology Molecular Function:
- sodium:phosphate symporter activity
sodium-dependent phosphate transmembrane transporter activity - Gene Ontology Cellular Component:
- apical plasma membrane
integral component of plasma membrane
membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Glycoprotein
Ion transport
Membrane
Polymorphism
Reference proteome
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport