Names & Taxonomy
- Uniprot ID:
- Q9Y286
- Entry Name:
- SIGL7_HUMAN
- Status:
- reviewed
- Protein Names:
- Sialic acid-binding Ig-like lectin 7 (Siglec-7) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (CDw328) (D-siglec) (QA79 membrane protein) (p75) (CD antigen CD328)
- Gene Names:
- SIGLEC7 AIRM1
- Gene Names Primary:
- SIGLEC7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 467
- Sequence:
- MLLLLLLPLLWGRERVEGQKSNRKDYSLTMQSSVTVQEGMCVHVRCSFSYPVDSQTDSDPVHGYWFRAGNDISWKAPVATNNPAWAVQEETRDRFHLLGDPQTKNCTLSIRDARMSDAGRYFFRMEKGNIKWNYKYDQLSVNVTALTHRPNILIPGTLESGCFQNLTCSVPWACEQGTPPMISWMGTSVSPLHPSTTRSSVLTLIPQPQHHGTSLTCQVTLPGAGVTTNRTIQLNVSYPPQNLTVTVFQGEGTASTALGNSSSLSVLEGQSLRLVCAVDSNPPARLSWTWRSLTLYPSQPSNPLVLELQVHLGDEGEFTCRAQNSLGSQHVSLNLSLQQEYTGKMRPVSGVLLGAVGGAGATALVFLSFCVIFIVVRSCRKKSARPAADVGDIGMKDANTIRGSASQGNLTESWADDNPRHHGLAAHSSGEEREIQYAPLSFHKGEPQDLSGQEATNNEYSEIKIPK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
carbohydrate binding
receptor activity
cell adhesion
regulation of immune response - Gene Ontology Biological Process:
- cell adhesion
regulation of immune response - Gene Ontology Molecular Function:
- carbohydrate binding
receptor activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell adhesion
Complete proteome
Disulfide bond
Glycoprotein
Immunoglobulin domain
Lectin
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix