Names & Taxonomy

Uniprot ID:
Q9Y285
Entry Name:
SYFA_HUMAN
Status:
reviewed
Protein Names:
Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (CML33) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS)
Gene Names:
FARSA FARS FARSL FARSLA
Gene Names Primary:
FARSA
Organism:
Homo sapiens (Human)

Structure

Length:
508
Sequence:
MADGQVAELLLRRLEASDGGLDSAELAAELGMEHQAVVGAVKSLQALGEVIEAELRSTKHWELTAEGEEIAREGSHEARVFRSIPPEGLAQSELMRLPSGKVGFSKAMSNKWIRVDKSAADGPRVFRVVDSMEDEVQRRLQLVRGGQAEKLGEKERSELRKRKLLAEVTLKTYWVSKGSAFSTSISKQETELSPEMISSGSWRDRPFKPYNFLAHGVLPDSGHLHPLLKVRSQFRQIFLEMGFTEMPTDNFIESSFWNFDALFQPQQHPARDQHDTFFLRDPAEALQLPMDYVQRVKRTHSQGGYGSQGYKYNWKLDEARKNLLRTHTTSASARALYRLAQKKPFTPVKYFSIDRVFRNETLDATHLAEFHQIEGVVADHGLTLGHLMGVLREFFTKLGITQLRFKPAYNPYTEPSMEVFSYHQGLKKWVEVGNSGVFRPEMLLPMGLPENVSVIAWGLSLERPTMIKYGINNIRELVGHKVNLQMVYDSPLCRLDAEPRPPPTQEAA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm

Function

Catalytic Activity:
ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).
Cross Reference Drug Bank:
DB00120
Gene Ontology Go:
cytoplasm
cytosol
membrane
phenylalanine-tRNA ligase complex
ATP binding
phenylalanine-tRNA ligase activity
poly(A) RNA binding
tRNA binding
gene expression
phenylalanyl-tRNA aminoacylation
tRNA aminoacylation for protein translation
Gene Ontology Biological Process:
gene expression
phenylalanyl-tRNA aminoacylation
tRNA aminoacylation for protein translation
Gene Ontology Molecular Function:
ATP binding
phenylalanine-tRNA ligase activity
poly(A) RNA binding
tRNA binding
Gene Ontology Cellular Component:
cytoplasm
cytosol
membrane
phenylalanine-tRNA ligase complex
Keywords:
3D-structure
ATP-binding
Acetylation
Alternative splicing
Aminoacyl-tRNA synthetase
Complete proteome
Cytoplasm
Direct protein sequencing
Ligase
Nucleotide-binding
Phosphoprotein
Polymorphism
Protein biosynthesis
Reference proteome
Interacts With:
Q9P2A4; Q9BQ95

Publication

PubMed ID:
9177188 10049785 14702039 15057824 15489334 12665801 18691976 19413330 19608861 21269460 22223895 22814378 25944712