Names & Taxonomy
- Uniprot ID:
- Q9Y285
- Entry Name:
- SYFA_HUMAN
- Status:
- reviewed
- Protein Names:
- Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (CML33) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS)
- Gene Names:
- FARSA FARS FARSL FARSLA
- Gene Names Primary:
- FARSA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 508
- Sequence:
- MADGQVAELLLRRLEASDGGLDSAELAAELGMEHQAVVGAVKSLQALGEVIEAELRSTKHWELTAEGEEIAREGSHEARVFRSIPPEGLAQSELMRLPSGKVGFSKAMSNKWIRVDKSAADGPRVFRVVDSMEDEVQRRLQLVRGGQAEKLGEKERSELRKRKLLAEVTLKTYWVSKGSAFSTSISKQETELSPEMISSGSWRDRPFKPYNFLAHGVLPDSGHLHPLLKVRSQFRQIFLEMGFTEMPTDNFIESSFWNFDALFQPQQHPARDQHDTFFLRDPAEALQLPMDYVQRVKRTHSQGGYGSQGYKYNWKLDEARKNLLRTHTTSASARALYRLAQKKPFTPVKYFSIDRVFRNETLDATHLAEFHQIEGVVADHGLTLGHLMGVLREFFTKLGITQLRFKPAYNPYTEPSMEVFSYHQGLKKWVEVGNSGVFRPEMLLPMGLPENVSVIAWGLSLERPTMIKYGINNIRELVGHKVNLQMVYDSPLCRLDAEPRPPPTQEAA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Catalytic Activity:
- ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).
- Cross Reference Drug Bank:
- DB00120
- Gene Ontology Go:
- cytoplasm
cytosol
membrane
phenylalanine-tRNA ligase complex
ATP binding
phenylalanine-tRNA ligase activity
poly(A) RNA binding
tRNA binding
gene expression
phenylalanyl-tRNA aminoacylation
tRNA aminoacylation for protein translation - Gene Ontology Biological Process:
- gene expression
phenylalanyl-tRNA aminoacylation
tRNA aminoacylation for protein translation - Gene Ontology Molecular Function:
- ATP binding
phenylalanine-tRNA ligase activity
poly(A) RNA binding
tRNA binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
membrane
phenylalanine-tRNA ligase complex - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Aminoacyl-tRNA synthetase
Complete proteome
Cytoplasm
Direct protein sequencing
Ligase
Nucleotide-binding
Phosphoprotein
Polymorphism
Protein biosynthesis
Reference proteome - Interacts With:
- Q9P2A4; Q9BQ95