Names & Taxonomy

Uniprot ID:
Q9Y275
Entry Name:
TN13B_HUMAN
Status:
reviewed
Protein Names:
Tumor necrosis factor ligand superfamily member 13B (B lymphocyte stimulator) (BLyS) (B-cell-activating factor) (BAFF) (Dendritic cell-derived TNF-like molecule) (TNF- and APOL-related leukocyte expressed ligand 1) (TALL-1) (CD antigen CD257) [Cleaved into: Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form]
Gene Names:
TNFSF13B BAFF BLYS TALL1 TNFSF20 ZTNF4 UNQ401/PRO738
Gene Names Orf:
UNQ401/PRO738
Gene Names Primary:
TNFSF13B
Organism:
Homo sapiens (Human)

Structure

Length:
285
Sequence:
MDDSTEREQSRLTSCLKKREEMKLKECVSILPRKESPSVRSSKDGKLLAATLLLALLSCCLTVVSFYQVAALQGDLASLRAELQGHHAEKLPAGAGAPKAGLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Single-pass type II membrane protein.; Tumor necrosis factor ligand superfamily member 13b, soluble form: Secreted.

Function

Function:
Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
Cross Reference Drug Bank:
DB08879
Gene Ontology Go:
cytoplasm
extracellular region
extracellular space
integral component of membrane
perinuclear region of cytoplasm
plasma membrane
receptor binding
cell proliferation
immune response
positive regulation of B cell proliferation
positive regulation of cell proliferation
signal transduction
tumor necrosis factor-mediated signaling pathway
Gene Ontology Biological Process:
cell proliferation
immune response
positive regulation of B cell proliferation
positive regulation of cell proliferation
signal transduction
tumor necrosis factor-mediated signaling pathway
Gene Ontology Molecular Function:
receptor binding
Gene Ontology Cellular Component:
cytoplasm
extracellular region
extracellular space
integral component of membrane
perinuclear region of cytoplasm
plasma membrane
Keywords:
3D-structure
Alternative splicing
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Cytokine
Direct protein sequencing
Disulfide bond
Glycoprotein
Immunity
Membrane
Polymorphism
Reference proteome
Secreted
Signal-anchor
Transmembrane
Transmembrane helix
Interacts With:
O14836

Publication

PubMed ID:
10331498 10359578 10398604 12867412 22749832 12975309 15057823 15489334 10973284 11853672 11827482 11862220