Names & Taxonomy
- Uniprot ID:
- Q9Y275
- Entry Name:
- TN13B_HUMAN
- Status:
- reviewed
- Protein Names:
- Tumor necrosis factor ligand superfamily member 13B (B lymphocyte stimulator) (BLyS) (B-cell-activating factor) (BAFF) (Dendritic cell-derived TNF-like molecule) (TNF- and APOL-related leukocyte expressed ligand 1) (TALL-1) (CD antigen CD257) [Cleaved into: Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form]
- Gene Names:
- TNFSF13B BAFF BLYS TALL1 TNFSF20 ZTNF4 UNQ401/PRO738
- Gene Names Orf:
- UNQ401/PRO738
- Gene Names Primary:
- TNFSF13B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 285
- Sequence:
- MDDSTEREQSRLTSCLKKREEMKLKECVSILPRKESPSVRSSKDGKLLAATLLLALLSCCLTVVSFYQVAALQGDLASLRAELQGHHAEKLPAGAGAPKAGLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Single-pass type II membrane protein.; Tumor necrosis factor ligand superfamily member 13b, soluble form: Secreted.
Function
- Function:
- Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
- Cross Reference Drug Bank:
- DB08879
- Gene Ontology Go:
- cytoplasm
extracellular region
extracellular space
integral component of membrane
perinuclear region of cytoplasm
plasma membrane
receptor binding
cell proliferation
immune response
positive regulation of B cell proliferation
positive regulation of cell proliferation
signal transduction
tumor necrosis factor-mediated signaling pathway - Gene Ontology Biological Process:
- cell proliferation
immune response
positive regulation of B cell proliferation
positive regulation of cell proliferation
signal transduction
tumor necrosis factor-mediated signaling pathway - Gene Ontology Molecular Function:
- receptor binding
- Gene Ontology Cellular Component:
- cytoplasm
extracellular region
extracellular space
integral component of membrane
perinuclear region of cytoplasm
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Cytokine
Direct protein sequencing
Disulfide bond
Glycoprotein
Immunity
Membrane
Polymorphism
Reference proteome
Secreted
Signal-anchor
Transmembrane
Transmembrane helix - Interacts With:
- O14836