Names & Taxonomy
- Uniprot ID:
- Q9Y271
- Entry Name:
- CLTR1_HUMAN
- Status:
- reviewed
- Protein Names:
- Cysteinyl leukotriene receptor 1 (CysLTR1) (Cysteinyl leukotriene D4 receptor) (LTD4 receptor) (G-protein coupled receptor HG55) (HMTMF81)
- Gene Names:
- CYSLTR1 CYSLT1
- Gene Names Primary:
- CYSLTR1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 337
- Sequence:
- MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.
- Cross Reference Drug Bank:
- DB00587 DB00471 DB00716 DB01411 DB00549
- Gene Ontology Go:
- integral component of plasma membrane
membrane
plasma membrane
cysteinyl leukotriene receptor activity
G-protein coupled peptide receptor activity
leukotriene receptor activity
calcium ion transport
cell surface receptor signaling pathway
chemotaxis
circulatory system process
defense response
neuropeptide signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
respiratory gaseous exchange - Gene Ontology Biological Process:
- calcium ion transport
cell surface receptor signaling pathway
chemotaxis
circulatory system process
defense response
neuropeptide signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
respiratory gaseous exchange - Gene Ontology Molecular Function:
- cysteinyl leukotriene receptor activity
G-protein coupled peptide receptor activity
leukotriene receptor activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix - Interacts With:
- Q9NS75