Names & Taxonomy

Uniprot ID:
Q9UPR5
Entry Name:
NAC2_HUMAN
Status:
reviewed
Protein Names:
Sodium/calcium exchanger 2 (Na(+)/Ca(2+)-exchange protein 2) (Solute carrier family 8 member 2)
Gene Names:
SLC8A2 KIAA1087 NCX2
Gene Names Primary:
SLC8A2
Organism:
Homo sapiens (Human)

Structure

Length:
921
Sequence:
MAPLALVGVTLLLAAPPCSGAATPTPSLPPPPANDSDTSTGGCQGSYRCQPGVLLPVWEPDDPSLGDKAARAVVYFVAMVYMFLGVSIIADRFMAAIEVITSKEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVCIYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLVFFPVCVVFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIELDGTFVGAEAPGELGGLGPGPAEARELDASRREVIQILKDLKQKHPDKDLEQLVGIANYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADASRRAAPAEGAGEDEDDGASRIFFEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRPKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGISALLLNQGDGDRKLTAEEEEARRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAITVSAGDEEEEEDGSREERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVFAFVGIAVLLYRRRPHIGGELGGPRGPKLATTALFLGLWLLYILFASLEAYCHIRGF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca(2+) and Na(+) excretion.
Enzyme Regulation:
ENZYME REGULATION: Calcium transport is down-regulated by Na(+) and stimulated by Ca(2+).
Gene Ontology Go:
basolateral plasma membrane
dendritic spine
integral component of plasma membrane
perikaryon
plasma membrane
calcium:sodium antiporter activity
metal ion binding
blood coagulation
calcium ion transmembrane transport
cardiac conduction
cell communication
cellular calcium ion homeostasis
ion transport
learning
long-term synaptic potentiation
memory
regulation of cardiac conduction
regulation of short-term neuronal synaptic plasticity
sodium ion transmembrane transport
transmembrane transport
Gene Ontology Biological Process:
blood coagulation
calcium ion transmembrane transport
cardiac conduction
cell communication
cellular calcium ion homeostasis
ion transport
learning
long-term synaptic potentiation
memory
regulation of cardiac conduction
regulation of short-term neuronal synaptic plasticity
sodium ion transmembrane transport
transmembrane transport
Gene Ontology Molecular Function:
calcium:sodium antiporter activity
metal ion binding
Gene Ontology Cellular Component:
basolateral plasma membrane
dendritic spine
integral component of plasma membrane
perikaryon
plasma membrane
Keywords:
Antiport
Calcium
Calcium transport
Calmodulin-binding
Cell membrane
Cell projection
Complete proteome
Glycoprotein
Ion transport
Membrane
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Signal
Sodium
Sodium transport
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
10470851 14702039 23506867 24501278