Names & Taxonomy

Uniprot ID:
Q9UPI3
Entry Name:
FLVC2_HUMAN
Status:
reviewed
Protein Names:
Feline leukemia virus subgroup C receptor-related protein 2 (Calcium-chelate transporter) (CCT)
Gene Names:
FLVCR2 C14orf58
Gene Names Primary:
FLVCR2
Organism:
Homo sapiens (Human)

Structure

Length:
526
Sequence:
MVNEGPNQEESDDTPVPESALQADPSVSVHPSVSVHPSVSINPSVSVHPSSSAHPSALAQPSGLAHPSSSGPEDLSVIKVSRRRWAVVLVFSCYSMCNSFQWIQYGSINNIFMHFYGVSAFAIDWLSMCYMLTYIPLLLPVAWLLEKFGLRTIALTGSALNCLGAWVKLGSLKPHLFPVTVVGQLICSVAQVFILGMPSRIASVWFGANEVSTACSVAVFGNQLGIAIGFLVPPVLVPNIEDRDELAYHISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSLSYALTSPDASYLGSIARLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRSKTYKETTLVVYIMTLVGMVVYTFTLNLGHLWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFTISQGQIIDNYGTKPGNIFLCVFLTLGAALTAFIKADLRRQKANKETLENKLQEEEEESNTSKVPTAVSEDHL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Function

Function:
Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism.
Gene Ontology Go:
integral component of membrane
plasma membrane
heme binding
heme transporter activity
heme transport
transmembrane transport
Gene Ontology Biological Process:
heme transport
transmembrane transport
Gene Ontology Molecular Function:
heme binding
heme transporter activity
Gene Ontology Cellular Component:
integral component of membrane
plasma membrane
Keywords:
Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
14729055 14702039 12508121 15489334 20823265 20206334 20518025 20690116