Names & Taxonomy

Uniprot ID:
Q9UP95
Entry Name:
S12A4_HUMAN
Status:
reviewed
Protein Names:
Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1)
Gene Names:
SLC12A4 KCC1
Gene Names Primary:
SLC12A4
Organism:
Homo sapiens (Human)

Structure

Length:
1085
Sequence:
MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERAELDDSDGHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Multi-pass membrane protein.

Function

Function:
Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity.
Enzyme Regulation:
ENZYME REGULATION: Inhibited by WNK3.
Cross Reference Drug Bank:
DB00887 DB00761
Gene Ontology Go:
integral component of plasma membrane
lysosomal membrane
membrane
plasma membrane
potassium ion symporter activity
potassium:chloride symporter activity
protein kinase binding
cell volume homeostasis
chloride transmembrane transport
chloride transport
ion transport
potassium ion transmembrane transport
synaptic transmission
transmembrane transport
transport
Gene Ontology Biological Process:
cell volume homeostasis
chloride transmembrane transport
chloride transport
ion transport
potassium ion transmembrane transport
synaptic transmission
transmembrane transport
transport
Gene Ontology Molecular Function:
potassium:chloride symporter activity
potassium ion symporter activity
protein kinase binding
Gene Ontology Cellular Component:
integral component of plasma membrane
lysosomal membrane
membrane
plasma membrane
Keywords:
Alternative splicing
Complete proteome
Glycoprotein
Ion transport
Membrane
Phosphoprotein
Potassium
Potassium transport
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
8663127 9516379 14702039 15616553 15489334 11551954 10564083 18669648 19690332 20068231 21613606 21406692 24275569