Names & Taxonomy
- Uniprot ID:
- Q9UP95
- Entry Name:
- S12A4_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1)
- Gene Names:
- SLC12A4 KCC1
- Gene Names Primary:
- SLC12A4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1085
- Sequence:
- MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERAELDDSDGHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by WNK3.
- Cross Reference Drug Bank:
- DB00887 DB00761
- Gene Ontology Go:
- integral component of plasma membrane
lysosomal membrane
membrane
plasma membrane
potassium ion symporter activity
potassium:chloride symporter activity
protein kinase binding
cell volume homeostasis
chloride transmembrane transport
chloride transport
ion transport
potassium ion transmembrane transport
synaptic transmission
transmembrane transport
transport - Gene Ontology Biological Process:
- cell volume homeostasis
chloride transmembrane transport
chloride transport
ion transport
potassium ion transmembrane transport
synaptic transmission
transmembrane transport
transport - Gene Ontology Molecular Function:
- potassium:chloride symporter activity
potassium ion symporter activity
protein kinase binding - Gene Ontology Cellular Component:
- integral component of plasma membrane
lysosomal membrane
membrane
plasma membrane - Keywords:
- Alternative splicing
Complete proteome
Glycoprotein
Ion transport
Membrane
Phosphoprotein
Potassium
Potassium transport
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport