Names & Taxonomy

Uniprot ID:
Q9UP52
Entry Name:
TFR2_HUMAN
Status:
reviewed
Protein Names:
Transferrin receptor protein 2 (TfR2)
Gene Names:
TFR2
Gene Names Primary:
TFR2
Organism:
Homo sapiens (Human)

Structure

Length:
801
Sequence:
MERLWGLFQRAQQLSPRSSQTVYQRVEGPRKGHLEEEEEDGEEGAETLAHFCPMELRGPEPLGSRPRQPNLIPWAAAGRRAAPYLVLTALLIFTGAFLLGYVAFRGSCQACGDSVLVVSEDVNYEPDLDFHQGRLYWSDLQAMFLQFLGEGRLEDTIRQTSLRERVAGSAGMAALTQDIRAALSRQKLDHVWTDTHYVGLQFPDPAHPNTLHWVDEAGKVGEQLPLEDPDVYCPYSAIGNVTGELVYAHYGRPEDLQDLRARGVDPVGRLLLVRVGVISFAQKVTNAQDFGAQGVLIYPEPADFSQDPPKPSLSSQQAVYGHVHLGTGDPYTPGFPSFNQTQFPPVASSGLPSIPAQPISADIASRLLRKLKGPVAPQEWQGSLLGSPYHLGPGPRLRLVVNNHRTSTPINNIFGCIEGRSEPDHYVVIGAQRDAWGPGAAKSAVGTAILLELVRTFSSMVSNGFRPRRSLLFISWDGGDFGSVGSTEWLEGYLSVLHLKAVVYVSLDNAVLGDDKFHAKTSPLLTSLIESVLKQVDSPNHSGQTLYEQVVFTNPSWDAEVIRPLPMDSSAYSFTAFVGVPAVEFSFMEDDQAYPFLHTKEDTYENLHKVLQGRLPAVAQAVAQLAGQLLIRLSHDRLLPLDFGRYGDVVLRHIGNLNEFSGDLKARGLTLQWVYSARGDYIRAAEKLRQEIYSSEERDERLTRMYNVRIMRVEFYFLSQYVSPADSPFRHIFMGRGDHTLGALLDHLRLLRSNSSGTPGATSSTGFQESRFRRQLALLTWTLQGAANALSGDVWNIDNNF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Single-pass type II membrane protein.; Isoform Beta: Cytoplasm

Function

Function:
Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation.
Cross Reference Drug Bank:
DB05260
Gene Ontology Go:
cytoplasmic vesicle
external side of plasma membrane
HFE-transferrin receptor complex
integral component of plasma membrane
co-receptor binding
glycoprotein binding
transferrin receptor activity
cellular iron ion homeostasis
cellular response to iron ion
ferrous iron import into cell
iron ion homeostasis
iron ion transport
positive regulation of endocytosis
positive regulation of peptide hormone secretion
positive regulation of protein maturation
positive regulation of transcription from RNA polymerase II promoter
receptor-mediated endocytosis
response to iron ion
transferrin transport
Gene Ontology Biological Process:
cellular iron ion homeostasis
cellular response to iron ion
ferrous iron import into cell
iron ion homeostasis
iron ion transport
positive regulation of endocytosis
positive regulation of peptide hormone secretion
positive regulation of protein maturation
positive regulation of transcription from RNA polymerase II promoter
receptor-mediated endocytosis
response to iron ion
transferrin transport
Gene Ontology Molecular Function:
co-receptor binding
glycoprotein binding
transferrin receptor activity
Gene Ontology Cellular Component:
cytoplasmic vesicle
external side of plasma membrane
HFE-transferrin receptor complex
integral component of plasma membrane
Keywords:
Alternative splicing
Cell membrane
Complete proteome
Cytoplasm
Disease mutation
Disulfide bond
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Signal-anchor
Transmembrane
Transmembrane helix

Publication

PubMed ID:
10409623 9799793 12853948 15489334 14702039 10802645 19159218 24275569 11313241 12130528 12150153 14633868