Names & Taxonomy
- Uniprot ID:
- Q9UNK4
- Entry Name:
- PA2GD_HUMAN
- Status:
- reviewed
- Protein Names:
- Group IID secretory phospholipase A2 (GIID sPLA2) (sPLA2-IID) (EC 3.1.1.4) (PLA2IID) (Phosphatidylcholine 2-acylhydrolase 2D) (Secretory-type PLA, stroma-associated homolog)
- Gene Names:
- PLA2G2D SPLASH
- Gene Names Primary:
- PLA2G2D
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 145
- Sequence:
- MELALLCGLVVMAGVIPIQGGILNLNKMVKQVTGKMPILSYWPYGCHCGLGGRGQPKDATDWCCQTHDCCYDHLKTQGCSIYKDYYRYNFSQGNIHCSDKGSWCEQQLCACDKEVAFCLKRNLDTYQKRLRFYWRPHCRGQTPGC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2-linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined.
- Catalytic Activity:
- Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; ; Note=Binds 1 Ca(2+) ion per subunit.;
- Active Site:
- ACT_SITE 67 67
- Gene Ontology Go:
- extracellular region
calcium ion binding
heparin binding
phospholipase A2 activity
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
glycerophospholipid biosynthetic process
inflammatory response
lipid catabolic process
negative regulation of T cell proliferation
phosphatidic acid biosynthetic process
phosphatidylcholine acyl-chain remodeling
phosphatidylethanolamine acyl-chain remodeling
phosphatidylglycerol acyl-chain remodeling
phosphatidylinositol acyl-chain remodeling
phosphatidylserine acyl-chain remodeling
phospholipid metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
glycerophospholipid biosynthetic process
inflammatory response
lipid catabolic process
negative regulation of T cell proliferation
phosphatidic acid biosynthetic process
phosphatidylcholine acyl-chain remodeling
phosphatidylethanolamine acyl-chain remodeling
phosphatidylglycerol acyl-chain remodeling
phosphatidylinositol acyl-chain remodeling
phosphatidylserine acyl-chain remodeling
phospholipid metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- calcium ion binding
heparin binding
phospholipase A2 activity - Gene Ontology Cellular Component:
- extracellular region
- Keywords:
- Calcium
Complete proteome
Disulfide bond
Glycoprotein
Hydrolase
Lipid degradation
Lipid metabolism
Metal-binding
Polymorphism
Reference proteome
Secreted
Signal