Names & Taxonomy

Uniprot ID:
Q9UNK4
Entry Name:
PA2GD_HUMAN
Status:
reviewed
Protein Names:
Group IID secretory phospholipase A2 (GIID sPLA2) (sPLA2-IID) (EC 3.1.1.4) (PLA2IID) (Phosphatidylcholine 2-acylhydrolase 2D) (Secretory-type PLA, stroma-associated homolog)
Gene Names:
PLA2G2D SPLASH
Gene Names Primary:
PLA2G2D
Organism:
Homo sapiens (Human)

Structure

Length:
145
Sequence:
MELALLCGLVVMAGVIPIQGGILNLNKMVKQVTGKMPILSYWPYGCHCGLGGRGQPKDATDWCCQTHDCCYDHLKTQGCSIYKDYYRYNFSQGNIHCSDKGSWCEQQLCACDKEVAFCLKRNLDTYQKRLRFYWRPHCRGQTPGC
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted

Function

Function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2-linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined.
Catalytic Activity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
Cofactor:
COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; ; Note=Binds 1 Ca(2+) ion per subunit.;
Active Site:
ACT_SITE 67 67
Gene Ontology Go:
extracellular region
calcium ion binding
heparin binding
phospholipase A2 activity
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
glycerophospholipid biosynthetic process
inflammatory response
lipid catabolic process
negative regulation of T cell proliferation
phosphatidic acid biosynthetic process
phosphatidylcholine acyl-chain remodeling
phosphatidylethanolamine acyl-chain remodeling
phosphatidylglycerol acyl-chain remodeling
phosphatidylinositol acyl-chain remodeling
phosphatidylserine acyl-chain remodeling
phospholipid metabolic process
small molecule metabolic process
Gene Ontology Biological Process:
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
glycerophospholipid biosynthetic process
inflammatory response
lipid catabolic process
negative regulation of T cell proliferation
phosphatidic acid biosynthetic process
phosphatidylcholine acyl-chain remodeling
phosphatidylethanolamine acyl-chain remodeling
phosphatidylglycerol acyl-chain remodeling
phosphatidylinositol acyl-chain remodeling
phosphatidylserine acyl-chain remodeling
phospholipid metabolic process
small molecule metabolic process
Gene Ontology Molecular Function:
calcium ion binding
heparin binding
phospholipase A2 activity
Gene Ontology Cellular Component:
extracellular region
Keywords:
Calcium
Complete proteome
Disulfide bond
Glycoprotein
Hydrolase
Lipid degradation
Lipid metabolism
Metal-binding
Polymorphism
Reference proteome
Secreted
Signal

Publication

PubMed ID:
10455175 11196711 14702039 16710414 15489334