Names & Taxonomy
- Uniprot ID:
- Q9UMX2
- Entry Name:
- OAZ3_HUMAN
- Status:
- reviewed
- Protein Names:
- Ornithine decarboxylase antizyme 3 (AZ3) (ODC-Az 3)
- Gene Names:
- OAZ3
- Gene Names Primary:
- OAZ3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 235
- Sequence:
- MPCKRCRPSVYSLSYIKRGKTRNYLYPIWSPYAYYLYCYKYRITLREKMLPRCYKSITYKEEEDLTLQPRSCLQCSESLVGLQEGKSTEQGNHDQLKELYSAGNLTVLATDPLLHQDPVQLDFHFRLTSQTSAHWHGLLCDRRLFLDIPYQALDQGNRESLTATLEYVEEKTNVDSVFVNFQNDRNDRGALLRAFSYMGFEVVRPDHPALPPLDNVIFMVYPLERDVGHLPSEPP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus. Cytoplasm
Function
- Function:
- Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to ODC1 without promoting its degradation (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells.
- Cross Reference Drug Bank:
- DB00129
- Gene Ontology Go:
- blood microparticle
cytosol
nucleus
ornithine decarboxylase inhibitor activity
putrescine transmembrane transporter activity
cellular nitrogen compound metabolic process
negative regulation of polyamine transmembrane transport
polyamine biosynthetic process
polyamine metabolic process
positive regulation of protein catabolic process
putrescine transport
regulation of cellular amino acid metabolic process
small molecule metabolic process
spermatogenesis - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
negative regulation of polyamine transmembrane transport
polyamine biosynthetic process
polyamine metabolic process
positive regulation of protein catabolic process
putrescine transport
regulation of cellular amino acid metabolic process
small molecule metabolic process
spermatogenesis - Gene Ontology Molecular Function:
- ornithine decarboxylase inhibitor activity
putrescine transmembrane transporter activity - Gene Ontology Cellular Component:
- blood microparticle
cytosol
nucleus - Keywords:
- Alternative splicing
Complete proteome
Cytoplasm
Nucleus
Phosphoprotein
Polyamine biosynthesis
Reference proteome
Ribosomal frameshifting - Interacts With:
- O14977; Q96A70; Q9H2G9; Q6P1W5; Q9UKT9; Q96JM7; P11926; Q04864