Names & Taxonomy
- Uniprot ID:
- Q9ULX7
- Entry Name:
- CAH14_HUMAN
- Status:
- reviewed
- Protein Names:
- Carbonic anhydrase 14 (EC 4.2.1.1) (Carbonate dehydratase XIV) (Carbonic anhydrase XIV) (CA-XIV)
- Gene Names:
- CA14 UNQ690/PRO1335
- Gene Names Orf:
- UNQ690/PRO1335
- Gene Names Primary:
- CA14
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 337
- Sequence:
- MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPDLPALQPHGYDQPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGGSEHQINSEATFAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSHLHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGEMLSLGVGILVGCLCLLLAVYFIARKIRKKRLENRKSVVFTSAQATTEA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Reversible hydration of carbon dioxide.
- Catalytic Activity:
- H(2)CO(3) = CO(2) + H(2)O.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=7.9 mM for CO(2)
- Enzyme Regulation:
- ENZYME REGULATION: Activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited by coumarins, saccharin, sulfonamide derivatives such as acetazolamide (AZA) and Foscarnet (phosphonoformate trisodium salt).
- Active Site:
- ACT_SITE 84 84 Proton acceptor.
- Cross Reference Drug Bank:
- DB00819 DB00909
- Gene Ontology Go:
- integral component of membrane
plasma membrane
carbonate dehydratase activity
metal ion binding
bicarbonate transport
small molecule metabolic process - Gene Ontology Biological Process:
- bicarbonate transport
small molecule metabolic process - Gene Ontology Molecular Function:
- carbonate dehydratase activity
metal ion binding - Gene Ontology Cellular Component:
- integral component of membrane
plasma membrane - Keywords:
- 3D-structure
Complete proteome
Disulfide bond
Glycoprotein
Lyase
Membrane
Metal-binding
Phosphoprotein
Reference proteome
Signal
Transmembrane
Transmembrane helix
Zinc