Names & Taxonomy

Uniprot ID:
Q9UL54
Entry Name:
TAOK2_HUMAN
Status:
reviewed
Protein Names:
Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2)
Gene Names:
TAOK2 KIAA0881 MAP3K17 PSK PSK1 UNQ2971/PRO7431
Gene Names Orf:
UNQ2971/PRO7431
Gene Names Primary:
TAOK2
Organism:
Homo sapiens (Human)

Structure

Length:
1235
Sequence:
MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSISASSQSSSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQRPPGLPLPIPGALGPPNTGTPIEQQPCSPGQEAVLDQRMLGEEEEAVGERRILGKEGATLEPKQQRILGEESGAPSPSPQKHGSLVDEEVWGLPEEIEELRVPSLVPQERSIVGQEEAGTWSLWGKEDESLLDEEFELGWVQGPALTPVPEEEEEEEEGAPIGTPRDPGDGCPSPDIPPEPPPTHLRPCPASQLPGLLSHGLLAGLSFAVGSSSGLLPLLLLLLLPLLAAQGGGGLQAALLALEVGLVGLGASYLLLCTALHLPSSLFLLLAQGTALGAVLGLSWRRGLMGVPLGLGAAWLLAWPGLALPLVAMAAGGRWVRQQGPRVRRGISRLWLRVLLRLSPMAFRALQGCGAVGDRGLFALYPKTNKDGFRSRLPVPGPRRRNPRTTQHPLALLARVWVLCKGWNWRLARASQGLASHLPPWAIHTLASWGLLRGERPTRIPRLLPRSQRQLGPPASRQPLPGTLAGRRSRTRQSRALPPWR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasmic vesicle membrane

Function

Function:
Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation.
Catalytic Activity:
ATP + a protein = ADP + a phosphoprotein.
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Enzyme Regulation:
ENZYME REGULATION: Selectively inhibited by the enantiopure organoruthenium inhibitor 9E1. Activated following arsenic trioxide (As(2)O(3)) treatment.
Active Site:
ACT_SITE 151 151 Proton acceptor.
Gene Ontology Go:
cytoplasm
cytoplasmic vesicle membrane
cytoplasmic, membrane-bounded vesicle
cytoskeleton
dendrite
integral component of membrane
nucleolus
nucleus
receptor complex
ATP binding
MAP kinase kinase kinase activity
mitogen-activated protein kinase kinase binding
protein serine/threonine kinase activity
actin cytoskeleton organization
activation of MAPKK activity
apoptotic process
cell migration
cellular response to DNA damage stimulus
focal adhesion assembly
G2 DNA damage checkpoint
positive regulation of JNK cascade
positive regulation of stress-activated MAPK cascade
protein targeting to membrane
regulation of apoptotic process
regulation of cell growth
regulation of cell shape
regulation of mitotic cell cycle
response to stress
stress-activated MAPK cascade
Gene Ontology Biological Process:
actin cytoskeleton organization
activation of MAPKK activity
apoptotic process
cell migration
cellular response to DNA damage stimulus
focal adhesion assembly
G2 DNA damage checkpoint
positive regulation of JNK cascade
positive regulation of stress-activated MAPK cascade
protein targeting to membrane
regulation of apoptotic process
regulation of cell growth
regulation of cell shape
regulation of mitotic cell cycle
response to stress
stress-activated MAPK cascade
Gene Ontology Molecular Function:
ATP binding
MAP kinase kinase kinase activity
mitogen-activated protein kinase kinase binding
protein serine/threonine kinase activity
Gene Ontology Cellular Component:
cytoplasm
cytoplasmic, membrane-bounded vesicle
cytoplasmic vesicle membrane
cytoskeleton
dendrite
integral component of membrane
nucleolus
nucleus
receptor complex
Keywords:
ATP-binding
Alternative splicing
Cell projection
Coiled coil
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Cytoskeleton
Kinase
Magnesium
Membrane
Nucleotide-binding
Nucleus
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase
Transferase
Transmembrane
Transmembrane helix

Publication

PubMed ID:
10660600 13679851 10048485 14702039 17974005 15616553 15489334 12975309 11279118 12639963 12665513 16893890 17396146 17158878 18691976 19226137 19369195 20159944 20068231 21269460 24275569