Names & Taxonomy
- Uniprot ID:
- Q9UL12
- Entry Name:
- SARDH_HUMAN
- Status:
- reviewed
- Protein Names:
- Sarcosine dehydrogenase, mitochondrial (SarDH) (EC 1.5.8.3) (BPR-2)
- Gene Names:
- SARDH DMGDHL1
- Gene Names Primary:
- SARDH
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 918
- Sequence:
- MASLSRALRVAAAHPRQSPTRGMGPCNLSSAAGPTAEKSVPYQRTLKEGQGTSVVAQGPSRPLPSTANVVVIGGGSLGCQTLYHLAKLGMSGAVLLERERLTSGTTWHTAGLLWQLRPSDVEVELLAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTGIRVWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAMHHAYVVTERIEGIQNMPNVRDHDASVYLRLQGDALSVGGYEANPIFWEEVSDKFAFGLFDLDWEVFTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPELRGFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRRFHHSLTDHPRWIRERSHESYAKNYSVVFPHDEPLAGRNMRRDPLHEELLGQGCVFQERHGWERPGWFHPRGPAPVLEYDYYGAYGSRAHEDYAYRRLLADEYTFAFPPHHDTIKKECLACRGAAAVFDMSYFGKFYLVGLDARKAADWLFSADVSRPPGSTVYTCMLNHRGGTESDLTVSRLAPSHQASPLAPAFEGDGYYLAMGGAVAQHNWSHITTVLQDQKSQCQLIDSSEDLGMISIQGPASRAILQEVLDADLSNEAFPFSTHKLLRAAGHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAGAKHGLINAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAFTCKLKSPVPFLGREALEQQRAAGLRRRLVCFTMEDKVPMFGLEAIWRNGQVVGHVRRADFGFAIDKTIAYGYIHDPSGGPVSLDFVKSGDYALERMGVTYGAQAHLKSPFDPNNKRVKGIY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix
Function
- Pathway:
- Amine and polyamine degradation; sarcosine degradation; formaldehyde and glycine from sarcosine: step 1/1.
- Catalytic Activity:
- Sarcosine + H(2)O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein.
- Cofactor:
- COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
- Gene Ontology Go:
- mitochondrial matrix
mitochondrion
flavin adenine dinucleotide binding
folic acid binding
sarcosine dehydrogenase activity
tetrahydrofolate interconversion - Gene Ontology Biological Process:
- tetrahydrofolate interconversion
- Gene Ontology Molecular Function:
- flavin adenine dinucleotide binding
folic acid binding
sarcosine dehydrogenase activity - Gene Ontology Cellular Component:
- mitochondrial matrix
mitochondrion - Keywords:
- Acetylation
Alternative splicing
Complete proteome
Disease mutation
FAD
Flavoprotein
Mitochondrion
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Transit peptide