Names & Taxonomy
- Uniprot ID:
- Q9UKG9
- Entry Name:
- OCTC_HUMAN
- Status:
- reviewed
- Protein Names:
- Peroxisomal carnitine O-octanoyltransferase (COT) (EC 2.3.1.137)
- Gene Names:
- CROT COT
- Gene Names Primary:
- CROT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 612
- Sequence:
- MENQLAKSTEERTFQYQDSLPSLPVPSLEESLKKYLESVKPFANQEEYKKTEEIVQKFQSGIGEKLHQKLLERAKGKRNWLEEWWLNVAYLDVRIPSQLNVNFAGPAAHFEHYWPPKEGTQLERGSITLWHNLNYWQLLRKEKVPVHKVGNTPLDMNQFRMLFSTCKVPGITRDSIMNYFRTESEGRSPNHIVVLCRGRAFVFDVIHEGCLVTPPELLRQLTYIHKKCHSEPDGPGIAALTSEERTRWAKAREYLIGLDPENLALLEKIQSSLLVYSMEDSSPHVTPEDYSEIIAAILIGDPTVRWGDKSYNLISFSNGVFGCNCDHAPFDAMIMVNISYYVDEKIFQNEGRWKGSEKVRDIPLPEELIFIVDEKVLNDINQAKAQYLREASDLQIAAYAFTSFGKKLTKNKMLHPDTFIQLALQLAYYRLHGHPGCCYETAMTRHFYHGRTETMRSCTVEAVRWCQSMQDPSVNLRERQQKMLQAFAKHNKMMKDCSAGKGFDRHLLGLLLIAKEEGLPVPELFTDPLFSKSGGGGNFVLSTSLVGYLRVQGVVVPMVHNGYGFFYHIRDDRFVVACSAWKSCPETDAEKLVQLTFCAFHDMIQLMNSTHL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Peroxisome
Function
- Function:
- Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester.
- Pathway:
- Lipid metabolism; fatty acid beta-oxidation.
- Catalytic Activity:
- Octanoyl-CoA + L-carnitine = CoA + L-octanoylcarnitine.
- Active Site:
- ACT_SITE 327 327 Proton acceptor.
- Cross Reference Drug Bank:
- DB00583
- Gene Ontology Go:
- intracellular membrane-bounded organelle
mitochondrion
peroxisomal matrix
peroxisome
carnitine O-octanoyltransferase activity
receptor binding
carnitine metabolic process
cellular lipid metabolic process
coenzyme A metabolic process
fatty acid beta-oxidation
fatty acid beta-oxidation using acyl-CoA oxidase
fatty acid metabolic process
fatty acid transport
generation of precursor metabolites and energy
medium-chain fatty acid metabolic process
response to drug
response to organonitrogen compound
small molecule metabolic process - Gene Ontology Biological Process:
- carnitine metabolic process
cellular lipid metabolic process
coenzyme A metabolic process
fatty acid beta-oxidation
fatty acid beta-oxidation using acyl-CoA oxidase
fatty acid metabolic process
fatty acid transport
generation of precursor metabolites and energy
medium-chain fatty acid metabolic process
response to drug
response to organonitrogen compound
small molecule metabolic process - Gene Ontology Molecular Function:
- carnitine O-octanoyltransferase activity
receptor binding - Gene Ontology Cellular Component:
- intracellular membrane-bounded organelle
mitochondrion
peroxisomal matrix
peroxisome - Keywords:
- Acetylation
Acyltransferase
Alternative splicing
Complete proteome
Fatty acid metabolism
Lipid metabolism
Peroxisome
Polymorphism
Reference proteome
Transferase
Transport