Names & Taxonomy
- Uniprot ID:
- Q9UK17
- Entry Name:
- KCND3_HUMAN
- Status:
- reviewed
- Protein Names:
- Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3)
- Gene Names:
- KCND3
- Gene Names Primary:
- KCND3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 655
- Sequence:
- MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNDSENNQESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHMGKTTSLIESQHHHLLHCLEKTTGLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHPGLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTIHIQGSEQPSLTTSRSSLNLKADDGLRPNCKTSQITTAIISIPTPPALTPEGESRPPPASPGPNTNIPSIASNVVKVSAL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
- Intramembrane:
- INTRAMEM 360 380 Pore-forming; Name=Segment H5.
Function
- Function:
- Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.
- Cross Reference Drug Bank:
- DB00321 DB06637 DB00280 DB00458
- Gene Ontology Go:
- dendrite
neuronal cell body
perinuclear endoplasmic reticulum
plasma membrane
sarcolemma
voltage-gated potassium channel complex
A-type (transient outward) potassium channel activity
ion channel binding
metal ion binding
cardiac conduction
cellular response to BMP stimulus
membrane repolarization
potassium ion export
potassium ion transport
protein homooligomerization
synaptic transmission - Gene Ontology Biological Process:
- cardiac conduction
cellular response to BMP stimulus
membrane repolarization
potassium ion export
potassium ion transport
protein homooligomerization
synaptic transmission - Gene Ontology Molecular Function:
- A-type (transient outward) potassium channel activity
ion channel binding
metal ion binding - Gene Ontology Cellular Component:
- dendrite
neuronal cell body
perinuclear endoplasmic reticulum
plasma membrane
sarcolemma
voltage-gated potassium channel complex - Keywords:
- 3D-structure
Alternative splicing
Brugada syndrome
Cell membrane
Cell projection
Complete proteome
Disease mutation
Ion channel
Ion transport
Membrane
Metal-binding
Neurodegeneration
Phosphoprotein
Polymorphism
Potassium
Potassium channel
Potassium transport
Reference proteome
Spinocerebellar ataxia
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel
Zinc - Interacts With:
- Q9NZI2