Names & Taxonomy
- Uniprot ID:
- Q9UIC8
- Entry Name:
- LCMT1_HUMAN
- Status:
- reviewed
- Protein Names:
- Leucine carboxyl methyltransferase 1 (EC 2.1.1.233) (Protein-leucine O-methyltransferase) ([Phosphatase 2A protein]-leucine-carboxy methyltransferase 1)
- Gene Names:
- LCMT1 LCMT CGI-68
- Gene Names Orf:
- CGI-68
- Gene Names Primary:
- LCMT1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 334
- Sequence:
- MATRQRESSITSCCSTSSCDADDEGVRGTCEDASLCKRFAVSIGYWHDPYIQHFVRLSKERKAPEINRGYFARVHGVSQLIKAFLRKTECHCQIVNLGAGMDTTFWRLKDEDLLPSKYFEVDFPMIVTRKLHSIKCKPPLSSPILELHSEDTLQMDGHILDSKRYAVIGADLRDLSELEEKLKKCNMNTQLPTLLIAECVLVYMTPEQSANLLKWAANSFERAMFINYEQVNMGDRFGQIMIENLRRRQCDLAGVETCKSLESQKERLLSNGWETASAVDMMELYNRLPRAEVSRIESLEFLDEMELLEQLMRHYCLCWATKGGNELGLKEITY
- Proteomes:
- UP000005640
Function
- Function:
- Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.
- Catalytic Activity:
- S-adenosyl-L-methionine + -leucine = S-adenosyl-L-homocysteine + -leucine methyl ester.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.1 uM for PP2AD
- Cross Reference Drug Bank:
- DB00149
- Gene Ontology Go:
- cytosol
protein C-terminal carboxyl O-methyltransferase activity
protein C-terminal leucine carboxyl O-methyltransferase activity
S-adenosylmethionine-dependent methyltransferase activity
C-terminal protein methylation
cellular protein modification process
negative regulation of protein complex assembly
protein methylation
regulation of apoptotic process
regulation of glucose metabolic process
regulation of mitotic cell cycle spindle assembly checkpoint - Gene Ontology Biological Process:
- cellular protein modification process
C-terminal protein methylation
negative regulation of protein complex assembly
protein methylation
regulation of apoptotic process
regulation of glucose metabolic process
regulation of mitotic cell cycle spindle assembly checkpoint - Gene Ontology Molecular Function:
- protein C-terminal carboxyl O-methyltransferase activity
protein C-terminal leucine carboxyl O-methyltransferase activity
S-adenosylmethionine-dependent methyltransferase activity - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Methyltransferase
Reference proteome
S-adenosyl-L-methionine
Transferase - Interacts With:
- P51116