Names & Taxonomy
- Uniprot ID:
- Q9UI40
- Entry Name:
- NCKX2_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium/potassium/calcium exchanger 2 (Na(+)/K(+)/Ca(2+)-exchange protein 2) (Retinal cone Na-Ca+K exchanger) (Solute carrier family 24 member 2)
- Gene Names:
- SLC24A2 NCKX2
- Gene Names Primary:
- SLC24A2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 661
- Sequence:
- MDLQQSTTITSLEKWCLDESLSGCRRHYSVKKKLKLIRVLGLFMGLVAISTVSFSISAFSETDTQSTGEASVVSGPRVAQGYHQRTLLDLNDKILDYTPQPPLSKEGESENSTDHAQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMKFNVQVEKWVKQMINRNKVVKVTAPEAQAKPSAARDKDEPTLPAKPRLQRGGSSASLHNSLMRNSIFQLMIHTLDPLAEELGSYGKLKYYDTMTEEGRFREKASILHKIAKKKCHVDENERQNGAANHVEKIELPNSTSTDVEMTPSSDASEPVQNGNLSHNIEGAEAQTADEEEDQPLSLAWPSETRKQVTFLIVFPIVFPLWITLPDVRKPSSRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAVSSNGLFCAIVLLFIMLLFVILSIALCKWRMNKILGFIMFGLYFVFLVVSVLLEDRILTCPVSI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
cadmium ion binding
calcium channel activity
calcium ion binding
calcium, potassium:sodium antiporter activity
manganese ion binding
nickel cation binding
potassium ion binding
sodium ion binding
symporter activity
cellular calcium ion homeostasis
ion transmembrane transport
ion transport
learning
long term synaptic depression
long-term synaptic potentiation
memory
response to stimulus
transmembrane transport
visual perception - Gene Ontology Biological Process:
- cellular calcium ion homeostasis
ion transmembrane transport
ion transport
learning
long term synaptic depression
long-term synaptic potentiation
memory
response to stimulus
transmembrane transport
visual perception - Gene Ontology Molecular Function:
- cadmium ion binding
calcium, potassium:sodium antiporter activity
calcium channel activity
calcium ion binding
manganese ion binding
nickel cation binding
potassium ion binding
sodium ion binding
symporter activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Antiport
Calcium
Calcium transport
Complete proteome
Glycoprotein
Ion transport
Membrane
Phosphoprotein
Potassium
Potassium transport
Reference proteome
Repeat
Sensory transduction
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport
Vision